Maternal Serum Adropin in Placenta Accreta Spectrum

Adana City Training and Research Hospital84 enrolled

Overview

Aim: To compare maternal serum adropin levels in pregnancies complicated by placenta previa and/or placenta accreta spectrum (PAS) with those of healthy pregnant women and to evaluate the diagnostic value of adropin for predicting placental invasion. Methods: This cross-sectional study included 84 singleton pregnancies at ≥34 weeks of gestation: 42 women diagnosed with placenta previa and/or PAS and 42 healthy pregnant women who underwent cesarean delivery. Maternal serum adropin levels are measured preoperatively using enzyme-linked immunosorbent assay. Demographic, obstetric, ultrasonographic, and intraoperative findings were recorded. Receiver operating characteristic (ROC) curve analysis is performed to assess the predictive performance of adropin for PAS.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Placenta Accreta Spectrum Placenta Previa

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Pregnant women aged 18-45 years in the reproductive period * Singleton, viable third-trimester pregnancies diagnosed with placenta previa and/or PAS Exclusion Criteria: * Uterine anomalies, * Chronic systemic diseases, * Multiple pregnancies, * Obstetric complications such as preterm premature rupture of membranes, threatened preterm labor, fetuses followed for intrauterine growth restriction, and placental abruption.

Locations (1)

Outcomes

Primary Outcomes

Blood serum Adropin levels

The aim of the present study was to evaluate maternal serum adropin levels in pregnancies complicated by placenta previa and placenta accreta spectrum and compare to healthy controls.

Time frame: From 15.04.2024 to 01.04.2025