Post-pyloric Feeding and Feeding Intolerance in ARDS Patients Receiving Prone Position Ventilation

Southeast University, China319 enrolled

Overview

Evidence remains limited regarding the optimal enteral nutrition (EN) route for acute respiratory distress syndrome (ARDS) patients undergoing prone positioning. This study aimed to explore the association of post-pyloric feeding with feeding intolerance (FI), specifically in that population.

This single-center retrospective study included adult patients with ARDS who received prone position ventilation at Zhongda Hospital, Southeast University, between July 30, 2016, and April 30, 2024. The primary outcome was the incidence of FI, defined as the failure to achieve an enteral energy intake of 17.5 kcal/kg/day within 72 hours of initiating EN. The statistical approaches utilized included multivariate regression, inverse probability weighting model, and marginal structural cox model to ensure the robustness of our findings. Subgroup analyses were also performed.

Study Type

OBSERVATIONAL

Enrollment

319

Conditions

Clinical Outcomes

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. age ≥ 18 years old 2. ARDS, defined by the Berlin standard 3. patients receiving prone position ventilation treatment Exclusion Criteria: 1. No enteral nutrition within 4 days after initiation of invasive mechanical ventilation 2. Duration of invasive mechanical ventilation \<72 hours after initiation of enteral nutrition 3. Prone positioning initiated \>3 days after EN 4. Duration of each prone session \<12 hours 5. Severe acute pancreatitis 6. Contraindications to early enteral nutrition

Outcomes

Primary Outcomes

Incidence of FI

Incidence of feeding intolerance during enteral nutrition within 72 hours of initiating EN

Time frame: at day 3

Secondary Outcomes

Incidence of enteral nutrition-related complications

Incidence of feeding-related complications during enteral nutrition

Time frame: up to 3 days

ICU mortality

the survival rate(survival/total) during ICU stay

Time frame: up to 24 months

28-day mortality

mortality in Day 28

Time frame: at day 28

VFDs at day 28

defined as the number of days between successful weaning from MV and day 28 after study enrollment

Time frame: 28 days

Length of ICU stay

the number of days from ICU admission to ICU discharge or death

Time frame: up to 24 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.