This is a single-center, open-label, split-face, site-randomized validation study, NB250045-NB-V designed to establish and confirm the reliability, reproducibility, and sensitivity of various skin measurement methods. Evaluator blinding will be implemented to minimize observer bias.
Each subject will serve as their own control, with right side of the face receiving the ceramide-containing moisturizer and the left side receiving water application as the control. This split-face approach reduces inter-subject variability and enables direct intra-individual comparison of the measurement methods across treated and control sites. The study involves a single on-site visit for each subject. * Baseline (pre-application): Subjects will undergo acclimatization in a controlled environment, after which baseline assessments will be performed for skin parameters on both test and control sites. * Application phase: The ceramide-containing moisturizer and water control will be applied to the randomized sites under investigator supervision. * Post-application assessments: Instrumental evaluations will be done at T15 mins following product application.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
15
The test cream was applied topically once daily to the designated treatment area. An adequate amount was gently massaged into clean, dry skin until fully absorbed. Participants were instructed not to wash the treated area for a specified period after application. The application procedure was standardized and followed consistently throughout the study duration.
To observe the effects of ceramide-containing moisturizer versus water application on skin parameters.
Change in Skin Glow and least reflection factor - assessed by Skin Glossymeter GL 200
Time frame: Change in the parameters at baseline (before application) and at post-application at T15 mins following application of the ceramide-containing moisturizer and water control.
To observe the effects of ceramide-containing moisturizer versus water application on skin parameters.
Change in Skin Hydration - assessed by Corneometer® CM 825
Time frame: Change in the parameters at baseline (before application) and at post-application at T15 mins following application of the ceramide-containing moisturizer and water control.
To observe the effects of ceramide-containing moisturizer versus water application on skin parameters.
Change in Trans epidermal water loss (TEWL) - assessed by Tewameter TM Hex
Time frame: Change in the parameters at baseline (before application) and at post-application at T15 mins following application of the ceramide-containing moisturizer and water control.
To observe the effects of ceramide-containing moisturizer versus water application on skin parameters.
Change in Skin Smoothness assessed by VisioScan® VC 20 Plus
Time frame: Change in the parameters at baseline (before application) and at post-application at T15 mins following application of the ceramide-containing moisturizer and water control.
To observe the effects of ceramide-containing moisturizer versus water application on skin parameters.
Change in Skin Roughness assessed by VisioScan® VC 20 Plus
Time frame: Change in the parameters at baseline (before application) and at post-application at T15 mins following application of the ceramide-containing moisturizer and water control.
Sheetal Khandwala
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To observe the effects of ceramide-containing moisturizer versus water application on skin parameters.
Change in Skin Scaliness assessed by VisioScan® VC 20 Plus
Time frame: Change in the parameters at baseline (before application) and at post-application at T15 mins following application of the ceramide-containing moisturizer and water control
To observe the effects of ceramide-containing moisturizer versus water application on skin parameters
Change in Sebum Level assessed by Sebumeter SM 825
Time frame: Change in the parameters at baseline (before application) and at post-application at T15 mins following application of the ceramide-containing moisturizer and water control