Bone Regeneration Using PRF After Cyst Enucleation

Sana'a University20 enrolled

Overview

This randomized controlled clinical trial aims to evaluate the clinical efficacy of autologous platelet-rich fibrin (PRF) in promoting osseous regeneration following cystic enucleation in the jaws. The study will assess bone healing outcomes and compare PRF application with conventional management methods.

This study is designed as a randomized controlled clinical trial to evaluate the effectiveness of autologous platelet-rich fibrin (PRF) in enhancing bone regeneration after cystic enucleation in the jaws. PRF is an autologous biomaterial rich in growth factors that may enhance bone healing and tissue regeneration. Participants undergoing cystic enucleation will be randomly assigned to either a PRF-treated group or a control group receiving conventional treatment without PRF. Clinical and radiographic assessments will be performed to evaluate bone regeneration, healing rate, and postoperative outcomes. If PRF demonstrates significant improvement in osseous regeneration, it may represent a minimally invasive and cost-effective alternative to traditional bone grafting procedures. Ethical approval will be obtained from the Ethical Committee of the Faculty of Medicine and Health Sciences, Sana'a University, Yemen.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Odontogenic Cyst Jaw Cysts Osseous Defect After Cyst Enucleation

Interventions

Autologous Platelet-Rich Fibrin (PRF)BIOLOGICAL

Autologous platelet-rich fibrin (PRF) prepared from the participant's own venous blood will be placed into the osseous defect immediately after cystic enucleation. PRF will be prepared using standard centrifugation protocols and applied to promote bone regeneration.

Conventional Surgical ManagementPROCEDURE

Conventional cystic enucleation will be performed without the use of platelet-rich fibrin (PRF). The osseous defect will be managed according to standard surgical protocol and allowed to heal naturally.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients diagnosed with odontogenic cysts requiring surgical enucleation. * Presence of a postoperative osseous defect in the jaws after cyst enucleation. * Age ≥ 18 years. * Systemically healthy patients (ASA I or II). * Patients willing to participate and sign informed consent. Exclusion Criteria: * Patients with systemic diseases affecting bone healing (e.g., uncontrolled diabetes, osteoporosis). * Patients receiving bisphosphonates or long-term corticosteroid therapy. * Smokers (\>10 cigarettes/day). * Pregnant or lactating women. * Patients with acute infection at the surgical site. * Patients unwilling to participate or unable to attend follow-up visits.

Locations (1)

Faculty of Medicine and Health Sciences - Sana'a University

Sanaa, Sanaa Governorate, Yemen

RECRUITING

Outcomes

Primary Outcomes

Radiographic bone regeneration in cystic defects following enucleation

The amount of bone regeneration will be evaluated radiographically using CBCT imaging to measure the percentage of defect fill and bone density changes at 6 months postoperatively.

Time frame: 6 months after surgery

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.