Early Myocardial Dysfunction Helps Identify Severe Refractory Pediatric Lupus

Shanghai Jiao Tong University School of Medicine60 enrolled

Overview

To investigate biomarkers to identify pediatric SR-SLE patients by non-invasive echocardiographic techniques.

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease. Although therapeutic advances have improved outcomes, a significant subset remains with severe disease activity despite optimal therapy, which is recognized as the severe refractory SLE (SR-SLE).A recent study using advanced echocardiographic techniques of global longitudinal strain (GLS) have revealed that left ventricular dysfunction is common in SLE patients and correlates with disease severity.The finding underscores the potential role of early myocardial dysfunction as a phenotypic marker of SR-SLE.To our knowledge, there are no validated biomarkers to reliably identify patients with SR-SLE at an early stage, especially in the pediatric population. Therefore, this study aimed to investigate biomarkers to identify pediatric SR-SLE patients.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Systemic Lupus Erythematosus (SLE)

Eligibility

Sex: ALLMin age: 7 YearsMax age: 17 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * fulfill the American College of Rheumatology (ACR) criteria * disease onset at ages before 18 years Exclusion Criteria: * patients with a history of concomitant malignancy * patients with active bacterial, viral, fungal, mycobacterial infection

Locations (1)

Shanghai Children's Medical Center

Shanghai, Shanghai Municipality, China

RECRUITING

Outcomes

Primary Outcomes

echocardiographic measurements

echocardiographic measurements including chamber dimensions, LV systolic and diastolic function, valve disease, strain values and etc..

Time frame: 6 months

Data from ClinicalTrials.gov

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