Exercise can reduce the risk of several chronic diseases. However, recent studies have suggested sitting for too long before exercising can decrease exercise benefits. This study will help determine why this may occur.
Previous work demonstrated a greater utilization of carbohydrates (CHO) at the end of aerobic exercise with a day of reduced activity (\<5,000 steps). Additionally, there are differences in the RNA profile at rest and during exercise in pathways related to inflammation, metabolism, and innate immunity that warrant further research. Together, these data highlight that a single day of reduced activity alters systemic homeostasis that affects the exercise response. Given the potency of exercise to ameliorate risk of cardiovascular disease, more research is needed to find factors to augment the exercise response. Therefore, this study has two goals: 1) Analyze circulating metabolomics, and 2) metabolomics and proteomics in response to exercise after a day of reduced activity.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
6
Subjects will walk less than 5,000 steps
Concordia University of Wisconsin
Mequon, Wisconsin, United States
RECRUITINGConcentration of metabolites within the plasma
We will collect blood before and immediately after exercise. Plasma will be separated and sent for untargeted metabolomic analysis.
Time frame: Participants will complete the study within 6 weeks of enrollment.
Concentration of proteins within the plasma
We will collect blood before and immediately after exercise. Plasma will be separated and sent for untargeted proteomic analysis.
Time frame: Participants will complete the study within 6 weeks of enrollment.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.