This study is designed to find out how safe nitroglycerin is and how it affects the body when it is taken together with another medicine called nurandociguat in people who have coronary artery disease (CAD). CAD is a condition where the arteries that supply blood to the heart become narrowed or blocked, often causing chest pain or even heart attacks. Many people with CAD also have chronic kidney disease (CKD), a long-term condition where the kidneys do not work as well as they should. People with CAD often use nitroglycerin to help improve blood flow to the heart. Nurandociguat is a new medicine being studied to help people with CKD by widening blood vessels and improving blood flow. Both nitroglycerin and nurandociguat work in similar ways in the body, so taking them together could have a stronger effect on blood vessels. This might lead to a sudden drop in blood pressure or other side effects. The main goal of this study is to learn how safe it is to use nitroglycerin and nurandociguat together, and to understand how they interact in the body.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
36
0.4 mg sublingual spray
Tablet, oral
Tablet matching nurandociguat, oral
Comac Medical | Phase I Clinical Research Unit
Sofia, Sofia City Province, Bulgaria
Universitätsklinikum Heidelberg - Zentrum für Innere Medizin, Abteilung Klinische Pharmakologie und Pharmakoepidemologie
Heidelberg, Baden-Wurttemberg, Germany
UK Bonn Institut für Klinische Chemie und Klinische Pharmakologie, Phase I Einheit und Arzneimitteltherapiesicherheit
Bonn, North Rhine-Westphalia, Germany
SocraTec R&D Erfurt-Clinical Pharmacology Unit
Erfurt, Thuringia, Germany
Deutsches Herzzentrum der Charité (DHZC) - Klinik für Kardiologie, Angiologie und Intensivmedizin CVK
Berlin, Germany
Number of participants with treatment-emergent adverse events per treatment group
The incidence of treatment-emergent adverse events will be summarized.
Time frame: Up to 7 days after the last treatment, for a total of up to about 7 weeks per participant
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