Early Pregnancy Serum Ferritin Levels as a Predictor for Gestational Diabetes Mellitus

Zagazig University556 enrolled

Overview

This prospective study evaluates a target population of pregnant women at the time of pregnancy diagnosis to investigate the predictive value of serum ferritin (SF) levels for the later development of gestational diabetes mellitus (GDM). The intervention involves measuring early-pregnancy SF, transferrin, and hemoglobin levels, alongside HbA1c, and comparing these biomarkers between women who later develop GDM and those who remain normoglycemic. The primary outcome is to assess the success rate of this diagnostic regimen in identifying high-risk individuals, aiming to establish SF as a valuable early biomarker for GDM to enable timely interventions.

Study Type

OBSERVATIONAL

Enrollment

556

Conditions

Diabetes Mellitus

Interventions

Glycemic MarkersDIAGNOSTIC_TEST

Fasting blood glucose (FBG), 2-h Post postprandial blood glucose (PPBG), HbA1c, and Fasting Serum Insulin (FSI).

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: * Confirmed pregnancy at an early gestational age. * Provision of clinical and family history (e.g., age, BMI, history of GDM). Exclusion Criteria: * Pre-existing Type 1 or Type 2 Diabetes Mellitus. * Conditions known to significantly alter iron metabolism independent of pregnancy.

Outcomes

Primary Outcomes

Success Rate of Diagnostic Regimens in Predicting Gestational Diabetes Mellitus

The efficacy of early pregnancy Serum Ferritin (SF) levels in accurately identifying women who will subsequently meet the diagnostic criteria for GDM.

Time frame: 24-28 weeks gestation

Secondary Outcomes

Iron Homeostasis Markers

Levels of serum transferrin and hemoglobin concentration as indicators of insulin resistance and diabetic risk.