This is a 4-week comparison study between the intervention and control sides of the face. Purposive sampling to recruit 13 patients with seborrheic dermatitis will be conducted in this study. The study will start after researcher has been granted the Ethic Committee Approval. The process of subject recruitment and clinical data collection will take place at the Outpatient Department (OPD) while photograph taking and skin measurement will take place at Laser Center and Bioengineering Department, respectively. All bioengineering instruments will be operated under the climate controlled environment; i.e, at temperature 20+/-2 degree Celsius and 50+/-2 % of relative humidity. A subject must get acclimatized to the ambient atmosphere for at least 30 minutes. The clinical data, skin barrier function, the quality of life, subject's satisfaction scale will be collected at the first day (D0, as baseline) and 4th week after finishing the test product (Wk4).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Enrollment
13
Antioxidant Moisturizing Serum
Institute of dermatology
Ratchathewi, Bangkok, Thailand
RECRUITINGSEDASI score
To compare clinical improvement as assessed by SEDASI score, between the intervention and control sides of the face in subjects with mild to moderate seborrheic dermatitis after 4 weeks of application of Institute of Dermatology's antioxidant moisturizing serum. This study uses split-face design. Due to the split-face study design and use of the SEDASI score, the same scoring scales were applied for extension (area, 0-6), presentation pattern (0-3), erythema (0-3), and scaling (0-3). The nasal area was excluded because split application to the nose is impractical. The original severity classification was therefore divided by two to obtain a hemiface-specific severity classification. Note: As the nasal area represents approximately 1% of the facial surface and the study compares the two sides of the face, this modification does not affect the primary study objective. The total score may range from 0 (no Seborrheic Dermatitis) to 30 (Seborrheic Dermatitis of the worst possible degree).
Time frame: 1 year
Skin Barrier function
To evaluate skin barrier function, as measured by transepidermal water loss (TEWL) and skin hydration, and surface lipid after 4 weeks of using IOD's antioxidant moisturizing serum. To evaluate facial skin appearance-including glossiness, desquamation, roughness, smoothness, wrinkles, elasticity, and redness-after 4 weeks of using IOD's antioxidant moisturizing serum.
Time frame: 4 weeks
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