This prospective cross-sectional study aims to evaluate the association between serum endocan, alarin, and galanin-like peptide levels and the stages of diabetic retinopathy (DR), as well as their relationship with optical coherence tomography (OCT) findings. A total of 120 participants will be included: 30 patients without diabetic retinopathy, 30 with non-proliferative diabetic retinopathy, 30 with proliferative diabetic retinopathy, and 30 healthy control subjects. In addition to routine preoperative blood sampling, an additional 5 mL of venous blood will be collected for biomarker analysis using ELISA. Macular and peripapillary retinal nerve fiber layer measurements will be obtained using OCT. Serum biomarker levels will be compared across DR stages and analyzed for correlation with OCT parameters.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
90
Collection of 5 mL of venous blood in addition to routine preoperative sampling for the measurement of serum endocan, alarin, and galanin-like peptide levels using ELISA.
Non-invasive optical coherence tomography imaging of the macula and peripapillary retinal nerve fiber layer using a Canon OCT device for structural retinal assessment.
Fethi Sekin City Hospital
Elâzığ, Elaziğ, Turkey (Türkiye)
Serum Endocan Level
Serum endocan concentration measured using ELISA and compared across diabetic retinopathy stages.
Time frame: At baseline (preoperative blood sampling)
Serum Alarin Level
Serum alarin concentration measured by ELISA and analyzed according to diabetic retinopathy severity.
Time frame: At baseline
Serum Galanin-Like Peptide Level
Serum galanin-like peptide concentration measured using ELISA and compared between study groups.
Time frame: At baseline
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