APPRAISE: Assessment of Pain and Posterior Synechiae Reduction With Atropine, an Investigation of Post-Surgical Eyes

Phase 4RecruitingNCT07434635

University of California, San Francisco62 enrolled

Overview

The study will evaluate whether atropine eyedrops are beneficial when used after certain eye surgeries.

Atropine eyedrops are often used after certain eye surgeries. This study will compare several outcomes following surgery in patients either using or not using this treatment.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Eye Disorders

Interventions

Atropine 1%DRUG

Subtraction of atropine eyedrops from post-operative treatment regimen

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patient undergoing vitrectomy surgery * able to give informed consent Exclusion Criteria: * post-operative eyedrop regimens that include topical non steroidal anti-inflammatory medications * subjects with altered post-operative eyedrop schedule for enhanced inflammation control * documented allergy to atropine

Locations (1)

University of California, San Francisco

San Francisco, California, United States

RECRUITING

Outcomes

Primary Outcomes

Pain score on the Visual Analog Scale (VAS)

Whether atropine use impacts post-operative pain score on the standard Visual Analog Scale (VAS)

Time frame: 1 month

Secondary Outcomes

Anterior chamber inflammation (aqueous cell and flare)

Whether atropine impacts the occurrence of post-operative inflammation, quantified as aqueous cell and flare, using the Standardization of Uveitis Nomenclature (SUN) Criteria

Time frame: 1 month

Cystoid macular edema detected by optical coherence tomography

Whether atropine impacts the occurrence of cystoid macular edema after surgery, detected by optical coherence tomography scanning of the retina

Time frame: 1 month

Time to visual recovery

Whether atropine impacts the time to visual recovery

Time frame: 1 month

Intraocular pressure

Whether atropine impacts intraocular pressure after surgery

Time frame: 1 month

Posterior synechiae formation

Presence or absence of posterior synechiae assessed by slit lamp examination at post-operative visits

Time frame: 1 month

Central Contacts

Jay Stewart, MD

CONTACT

415-353-9635 eyestudy@ucsf.edu

Data from ClinicalTrials.gov

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