This study is testing a new medicine, NNC6989-0001, to test it is safe and tolerable for healthy people living with overweight or obesity. NNC6989-0001 is still being tested in studies and is not yet available for prescription by doctors. In this study, participants will receive either NNC6989-0001 or a placebo; which treatment each participant receives will be decided by chance.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
132
Participants assigned to the active intervention receive NNC6989-0001
Participants assigned to the placebo, receive placebo matched in appearance to the active drug.
ICON Early Phase Services, LLC
Lenexa, Kansas, United States
RECRUITINGNumber of treatment emergent adverse events (TEAE) - Part A
Measure in number of events.
Time frame: From time of dosing on Day1 until completion of the end of study visit (Day 7)
Number of treatment emergent adverse events (TEAE) - Part B
Measured in number of events
Time frame: From time of dosing on Day 1 until completion of the end of study visit (Day 14)
iAUCTG; The incremental area under the blood triglycerides concentration-time curve following meal test - Part C
Measured in ratio
Time frame: Following meal test at Day -1, Day 1, Day 7 and Day 13
AUC; the area under the NNC6989-0001 plasma concentration-time curve - Part A
Measured in hours times nanograms per millilitre(h\*ng/ml).
Time frame: From pre-dose on Day 1 until completion of the end of study visit (Day 7)
Cmax; the maximum plasma concentration of NNC6989-0001 - Part A
Measured in nanograms per millilitre(ng/ml).
Time frame: From pre-dose on Day 1 until completion of the end of study visit (Day 7)
AUC; the area under the NNC6989-0001 plasma concentration-time curve - Part B
Measured in h\*ng/ml.
Time frame: From pre-dose on Day 1 until completion of the end of study visit (Day 14)
Cmax; the maximum plasma concentration of NNC6989-0001 - Part B
Measured in ng/ml.
Time frame: From pre-dose on Day 1 until completion of the end of study visit (Day 14)
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AUC; the area under the NNC6989-0001 plasma concentration-time curve - Part C
Measured in h\*ng/ml.
Time frame: From pre-dose on Day 1 until completion of the end of study visit (Day 20)
Cmax; the maximum plasma concentration of NNC6989-0001 - Part C
Measured in ng/ml.
Time frame: From pre-dose on Day 1 until completion of the end of study visit (Day 20)