Effects of the Adjunctive Use of Hyaluronic Acid-based Gel With Coranally Advanced Flap in the Gingival Recession

Ordu University20 enrolled

Overview

The study aimed to evaluate the effect of Hyaluronic Acid-based gel use in addition to the coronally advanced flap (CAF) technique in type 1 gingival recession (RT1) on postoperative morbidity, clinical parameters, and patient satisfaction, analyzed at baseline and 6 months.

The aim of this study is to evaluate the effect of HA use in addition to the coronally advanced flap (CAF) technique in type 1 gingival recession (RT1) on postoperative morbidity, clinical parameters, and patient satisfaction, analyzed at baseline and 6 months. This split-mouth study included 20 patients (9 males, 11 females) with a mean age of 42.10±9.46 years who were diagnosed with bilateral RT1 gingival recession in the maxilla. The right and left defect areas of the 20 patients were randomly assigned to two groups. The control group received CAF (n=20), and the test group received CAF+HA (n=20). Pre-treatment plaque index (PI), gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL), vertical recession depth (VRD), horizontal recession width (HRW), gingival thickness (GT), attached gingival (AG), and keratinized gingival width (KGW) were recorded. Additionally, a satisfaction analysis was conducted, including patient-based comfort (PBC), aesthetic (PEA), and sensitivity (PHS) scores. During the operation, a 0.8% HA gel was applied to the defect areas in the test group, in addition to CAF, while saline was applied to the control group, also in addition to CAF. Pain, bleeding, and edema scores, as well as the amount of painkillers, were recorded during the 9-day postoperative period. Clinical parameter measurements and patient satisfaction analyses were repeated 6 months after surgical treatment.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Gingival Recession

Interventions

Hyaluronic acidDRUG

0.8% hyaluronic acid gel (Gengigel Oral Forte Gel, Ricefarma, Milan, Italy)

Steril saline solutionOTHER

Mix 8 teaspoons of salt into 4 L of distilled water

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Double-sided type 1 gingival recession * No inflammation Exclusion Criteria: * active periodontal disease * smokers * pregnant and breastfeeding women * individuals with unilateral GR

Locations (1)

Figen Öngöz Dede

Ordu, Turkey (Türkiye)

Outcomes

Primary Outcomes

Complete root coverage

for evaluating rate of complete root coverage

Time frame: 6 months postsurgery

Mean root coverage

for evaluating rate of mean root coverage

Time frame: 6 months postsurgery

Secondary Outcomes

Plaque Index

to assess plaque accumulation

Time frame: Baseline

Plaque Index

to assess plaque accumulation

Time frame: 6 months post surgery

Gingival Index

for evaluating gingival inflammation

Time frame: Baseline

Gingival index

for evaluating gingival inflammation

Time frame: 6 montsh post surgery

Probing pocket depth

for measuring disease severity

Time frame: Baseline

Probing pocket depth

for measuring disease severity

Time frame: 6 months post surgery

Clinical attachment level

Clinical attachment level (CAL) is calculated by adding or subtracting probing depth (PD) and gingival recession (GR). The formula is CAL = PD + GR. CAL is measured in millimeters.

Time frame: Baseline

Data from ClinicalTrials.gov

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