The objective of this study was to compare and evaluate the effects of concentrated growth factor (CGF) and advanced platelet-rich fibrin (A-PRF) clot membranes on palatal epithelial wound healing and postoperative discomfort following free gingival graft (FGG) harvesting.
The objective of this study was to compare and evaluate the effects of concentrated growth factor (CGF) and advanced platelet-rich fibrin (A-PRF) clot membranes on palatal epithelial wound healing and postoperative discomfort following free gingival graft (FGG) harvesting. Fourty-five patients who underwent FGG harvesting were randomly assigned to three groups: (1) control group (n=15), receiving only a sterile gelatin sponge; (2) A-PRF group (n=15), receiving A-PRF clot membranes; and (3) CGF group (n=15), receiving CGF clot membranes at the donor site. The epithelization rate, color match, and sensation scores of the palatal wound were assessed at 1, 2, 3, and 4 weeks postoperatively. Pain levels, analgesic consumption, and bleeding time were self-reported by patients for the first 7 days of healing.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
45
Advanced platelet-rich fibrin membranes and free gingival graft
Concentrated growth factor membranes and free gingival graft
Sterile gelatin sponge and free gingival graft
Ordu University
Ordu, Turkey (Türkiye)
Epithelialization
Rate of re-epithelialization with re-total, partial, or none by dropping hydrogen peroxide (3%) on the wound surface
Time frame: Baseline
Epithelialization
Rate of re-epithelialization with re-total, partial, or none by dropping hydrogen peroxide (3%) on the wound surface
Time frame: 1 week post-surgery
Epithelialization
Rate of re-epithelialization with re-total, partial, or none by dropping hydrogen peroxide (3%) on the wound surface
Time frame: 2 week post-surgery
Epithelialization
Rate of re-epithelialization with re-total, partial, or none by dropping hydrogen peroxide (3%) on the wound surface
Time frame: 3 week post-surgery
Epithelialization
Rate of re-epithelialization with re-total, partial, or none by dropping hydrogen peroxide (3%) on the wound surface
Time frame: 4 week post-surgery
Pain perception
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Time frame: Baseline
Pain perception
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Time frame: 1st day after surgery
Pain perception
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
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Time frame: 2nd day after surgery
Pain perception
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Time frame: 3th day after surgery
Pain perception
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Time frame: 4th day after surgery
Pain perception
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Time frame: 5th day after surgery
Pain perception
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Time frame: 6th day after surgery
Pain perception
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Time frame: 7th day after surgery
Pain perception
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Time frame: 14th day after surgery
Pain perception
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Time frame: 21st day after surgery
Pain perception
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Time frame: 28th day after surgery