Simplified Dual Regimen Guided by Fecal Clarithromycin Resistance Gene Detection for First-line H. Pylori Eradication

Inclusion Criteria: 1. Aged 18-70 years; 2. Positive results for both ¹³C-urea breath test (¹³C-UBT) and fecal polymerase chain reaction (PCR), confirming Helicobacter pylori infection, with a clinical indication for H. pylori eradication as judged by the physician; 3. Treatment-naïve individuals with no prior history of H. pylori eradication therapy. Exclusion Criteria: 1. Pregnant or lactating women 2. Patients with a history of allergy to any drugs used in the eradication regimen 3. Patients with severe systemic diseases or malignant tumors 4. History of gastric resection surgery 5. Recent use of antibiotics or bismuth salts (within 4 weeks), H₂-receptor antagonists, proton pump inhibitors (PPIs), or Potassium-competitive acid blockers(P-CABs) (within 2 weeks).