triPle Oral thERapy With Bempedoic Acid vs uSual Care in Early Lipid Management of Patients With acUte coronAry synDromE

Inclusion Criteria: * Age ≥18 years * Male and females at birth * Admitted for ACS caused by an atherothrombotic coronary event; * Calculated LDL-c: 70-140 mg/dL within 24 hours from admission for the ACS index event * Lipid lowering therapy on admission consisting of a low/moderate intensity statin or a high intensity statin (HIS); or no lipid lowering therapy (naïve patients) * Lipid-lowering therapy at discharge (at the time of randomization) consisting of HIS or HIS + ezetimibe * Scheduled home discharge * Written informed consent provided; patients who are unable to give informed consent for any reason will be excluded from the study. Exclusion Criteria: * Patients already treated with HIS+Ezetimibe on admission for the ACS event, * Patients currently, previously or planned to be treated with PCSK9i or inclisiran, * Patients treated currently or in the last 3 months with bempedoic acid or in whom this treatment is planned in the following 8 weeks, * Known allergy, sensitivity or intolerance to bempedoic acid and/or study drugs' formulation ingredients (e.g. lactose intolerance), * Patients with history of documented intolerance to statins, ezetimibe or bempedoic acid * Patients with known Familial Hypercholesterolemia (FH; heterozygous or homozygous), * Patients with plasma triglycerides concentration exceeding 400 mg/dL (4.52 mmol/L), * Patients with dysbetalipoproteinemia (type III hyperlipoproteinemia), * Unstable clinical status (hemodynamic or electrical instability), * Severe renal dysfunction (eGFR \<30 ml/min/1.73m2 using the CKD-EPI formula), * Active liver disease or hepatic dysfunction (AST or ALT levels \> 3xUNL), * Current enrolment in another investigational device or drug study, * Current pregnancy, lactation or women of childbearing potential, unless using highly effective contraception, * Patients unlikely to comply with the protocol or unable to understand the nature, scope and possible consequences of the study.