The Factors Influencing the Success of Redo Surgery and Anal Function for Anastomosis Failure or Local Tumor Recurrence

Cancer Institute and Hospital, Chinese Academy of Medical Sciences143 enrolled

Overview

To analyze the influencing factors of the success of redo surgery due to anastomotic fistula or anastomotic recurrence after rectal cancer surgery and to evaluate the anal function of patients

Redo surgery is a critical salvage strategy for anastomotic complications or local recurrence following rectal cancer resection. Despite technical feasibility, functional outcomes remain suboptimal. This study evaluated intestinal continuity restoration and anal function recovery after redo surgery, alongside prognostic factors influencing outcomes. A retrospective multicenter study analyzed 143 patients undergoing redo surgery (2015-2023) for anastomotic failure or local recurrence. Primary endpoints included anatomical restoration of intestinal continuity, while secondary endpoints assessed functional outcomes using the LARS score.

Study Type

OBSERVATIONAL

Enrollment

143

Conditions

Colo-rectal Cancer Anastomosis, Leaking

Interventions

redo surgeryPROCEDURE

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Prior curative resection for primary colorectal adenocarcinoma. * Subsequent reoperation for anastomotic failure or locoregional recurrence. * Absence of absolute contraindications to reoperative surgery. Exclusion Criteria: * Primary tumors located proximal to the sigmoid colon. * Radiologically confirmed distant metastases. * Presence of a permanent stoma at the time of questionnaire administration. * Insufficient literacy or cognitive function to complete study-related -questionnaires.

Outcomes

Primary Outcomes

Whether postoperative patients with rectal cancer can restore intestinal continuity, that is, defecate through the anus

Time frame: During the follow-up period, at least two years after rectal cancer surgery

Secondary Outcomes

Low Anterior Rectal Syndrome (LARS) Score of patients restoring intestinal continuity

Time frame: During the follow-up period, at least one year has passed since the intestinal continuity was restored

Data from ClinicalTrials.gov

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