The overall objective of the research project presented here is to assess the prevalence of fibromyalgia in patients being treated for ADHD, the prevalence of ADHD in patients being treated for fibromyalgia, and the neurobiological correlates of ADHD-fibromyalgia comorbidity.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
100
Blood and urine samples including metabolomic analyses. Completing self-assessment questionnaires. Assessment of sensitivity to mechanical pain (by using the Von Frey monofilament test)
Percentage of patients with fibromyalgia among patients with ADHD and no prior methylphenidate treatment
Comparison of the observed prevalence of fibromyalgia (as assessed by the ACR diagnostic criteria) among patients with ADHD (as assessed by the DIVA-5 diagnostic interview) and no prior methylphenidate treatment versus the theoretical prevalence of fibromyalgia in the overall French population
Time frame: Baseline
Percentage of patients with fibromyalgia among patients with ADHD and a current methylphenidate treatment
Comparison of the observed prevalence of fibromyalgia (as assessed by the ACR diagnostic criteria) among patients with ADHD (as assessed by the DIVA-5 diagnostic interview) and a current methylphenidate treatment versus the theoretical prevalence of fibromyalgia in the French overall population
Time frame: Baseline
Comparison of the levels of cytokines (specific biomarkers of inflammation), between patients with fibromyalgia without ADHD
Plasma and urine levels of different cytokines (IFN-gamma, IL-1B, IL-6, IL10, IL-13, IL-17, TNF-alpha), as assessed by metabolomic analyses (high-performance liquid chromatography)
Time frame: Baseline
Comparison of the levels of cytokines (specific biomarkers of inflammation), between patients with ADHD without fibromyalgia
Plasma and urine levels of different cytokines (IFN-gamma, IL-1B, IL-6, IL10, IL-13, IL-17, TNF-alpha), as assessed by metabolomic analyses (high-performance liquid chromatography)
Time frame: Baseline
Comparison of the levels of cytokines (specific biomarkers of inflammation), between patients with fibromyalgia with ADHD
Plasma and urine levels of different cytokines (IFN-gamma, IL-1B, IL-6, IL10, IL-13, IL-17, TNF-alpha), as assessed by metabolomic analyses (high-performance liquid chromatography)
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Time frame: Baseline
Comparison of the levels of neuro-inflammation biomarkers (i.e., tryptophane derivatives, short carbon chain fatty acids, lipidomic profile) between patients with fibromyalgia without ADHD,
Plasma and urine levels of tryptophane derivatives, short carbon chain fatty acids and lipidomic profile, as assessed by metabolomic analyses
Time frame: Baseline
Comparison of the levels of neuro-inflammation biomarkers (i.e., tryptophane derivatives, short carbon chain fatty acids, lipidomic profile) between patients with ADHD without fibromyalgia
Plasma and urine levels of tryptophane derivatives, short carbon chain fatty acids and lipidomic profile, as assessed by metabolomic analyses
Time frame: Baseline
Comparison of the levels of neuro-inflammation biomarkers (i.e., tryptophane derivatives, short carbon chain fatty acids, lipidomic profile) between patients with fibromyalgia with ADHD
Plasma and urine levels of tryptophane derivatives short carbon chain fatty acids and lipidomic profile, as assessed by metabolomic analyses
Time frame: Baseline
Comparison of the levels of 500 biomarkers of neurotransmission between patients with fibromyalgia without ADHD
Plasma and urine levels of 500 different biomarkers of neurotransmission (e.g., dopaminergic, serotoninergic, noradrenegic), as assessed by metabolomic analyses (high-performance liquid chromatography)
Time frame: Baseline
Comparison of the levels of 500 biomarkers of neurotransmission between patients with: ADHD without fibromyalgia
Plasma and urine levels of 500 different biomarkers of neurotransmission (e.g., dopaminergic, serotoninergic, noradrenegic), as assessed by metabolomic analyses (high-performance liquid chromatography)
Time frame: Baseline
Comparison of the levels of 500 biomarkers of neurotransmission between patients with fibromyalgia with ADHD
Plasma and urine levels of 500 different biomarkers of neurotransmission (e.g., dopaminergic, serotoninergic, noradrenegic), as assessed by metabolomic analyses (high-performance liquid chromatography)
Time frame: Baseline