Impact of Time-restricted Eating on Sleep, Glucose and Insulin Sensitivity

Colorado State University13 enrolled

Overview

The purpose of this research study is to see how the timing of eating impacts participants sleep and how the body responds to sugar.

This research study is aimed to answer how the timing of eating impacts participants sleep and how the body responds to sugar. Participants must be healthy and between the ages of 18-65 to join . This research study will take 2 weeks of outpatient monitoring, and 2 different nights staying in the Sleep and Metabolism Lab. There are some risks to participating in this study, like hunger, skin irritation, discomfort with blood draws, and uncomfortableness while being observed. The investigators hope that this research will benefit the knowledge learned about circadian rhythms and metabolic disease and how the timing of eating affects these things.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Time Restricted Eating

Interventions

Time restricted eatingOTHER

For the week between the first and second overnight stay participants will be scheduled to eat a normal food quantity, but in a shorter period of time based on timing discussed with study staff. Typically, this will mean they will stop eating sometime in the afternoon and not eat again until breakfast the following day.

Control eatingOTHER

Participants consume a normal eating schedule across the day.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy adult men and women ages 18-65 * habitual sleep duration between 7-9.25 hours * lived at altitude for at least 3 months. Exclusion Criteria: * Diagnosed acute or chronic physical or psychiatric disorders; * diagnosed sleep disorders; * not participating in another research study concurrently which could increase risks, such as those involving medication or blood sampling; * shiftwork in the 6 months before the study; travel more then one time zone three weeks prior to the study; * blood donation 30 days prior to the first study visit; * illicit drug use, prescribed medication use (excluding over the counter products) 30 days prior to the study visit; * everyday nicotine use; * regular consumption of over 400mg caffeine per day in the past month; and consumption of over 14 alcoholic beverages a week, or more than 4 alcoholic beverages in a single day over the past month for men and consumption of over 7 alcoholic beverages a week, or more than 3 alcoholic beverages in a single day over the past month for women.

Locations (1)

Sleep and Metabolism Laboratory

Fort Collins, Colorado, United States

Outcomes

Primary Outcomes

24 hour Continuous Glucose Monitoring (Average glucose)

Participants will wear a continuous glucose monitor for 2 weeks. Week 1 will be compared to week 2.

Time frame: 2 weeks

Oral glucose tolerance test (2 hour glucose)

Participants will complete an oral glucose tolerance test on 2 occasions (end of week 1 and end of week 2)

Time frame: 2 weeks

Data from ClinicalTrials.gov

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