Effect of 8 Weeks of Resistance Training With Blood Flow Restriction on Muscle Strength, Clinical Parameters, Biochemical Biomarkers, and Perceived Exertion in Adults With Obesity

N/AEnrolling By InvitationNCT07444736

Centro Universitario de Tlajomulco, Universidad de Guadalajara30 enrolled

Overview

To analyze the effect of 8 weeks of resistance training with blood flow restriction on muscle strength, clinical parameters, biochemical biomarkers, and perceived exertion in adults with obesity.

Resistance training has been demonstrated to be an effective intervention for improving muscular strength and metabolic profile. According to the available evidence, a moderate-to-high intensity level (60-90% of one-repetition maximum \[1RM\]) is required to achieve optimal outcomes in healthy adults. Blood flow restriction (BFR) training, in turn, has emerged as an innovative strategy that promotes gains comparable or similar to those achieved with moderate-to-high intensity resistance training. It has been proposed as an efficient and safe training alternative in both clinical and non-clinical settings . Current findings identify BFR as a promising, versatile, accessible, and particularly useful tool when moderate-to-high intensity resistance training must be limited or contraindicated. Therefore, the present study aims to evaluate the effects of 8 weeks of resistance training combined with blood flow restriction on muscular strength, clinical parameters, biochemical biomarkers, and perceived exertion in adults with obesity, providing evidence regarding a potentially safe and effective intervention.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Obesity & Overweight

Interventions

InterventionOTHER

The BFR group will perform machine-based quadriceps extension exercises and dumbbell biceps curls involving both lower limbs and both upper limbs. Each exercise will consist of 4 sets of 12 repetitions. Quadriceps extensions will be performed at an intensity of 40% of one-repetition maximum (1RM), and biceps curls at 20% of 1RM. The execution cadence will be standardized to 1 second for the concentric phase and 2 seconds for the eccentric phase. Inter-set rest intervals will be 1 minute. For vascular occlusion, a Carbafix cuff (8 cm width × 68 cm length for the upper limb; 10.5 cm width × 106.0 cm length for the lower limb) will be applied directly to the skin at the most proximal portion of the arm or thigh. The cuff will be inflated to 20 mmHg above resting brachial systolic blood pressure. To ensure partial vascular occlusion, pulse and oxygen saturation will be assessed using a pulse oximeter at the end of each set. Cuff pressure will be released during the inter-set rest periods.

InterventionOTHER

The control group will perform quadriceps extensions and biceps curls, completing 4 sets of 10 repetitions at an intensity of 70% of one-repetition maximum (1RM). The execution tempo will be standardized to 1 second for the concentric phase and 2 seconds for the eccentric phase, with 2-minute inter-set rest intervals. The protocol will adhere to the resistance training guidelines established by the American College of Sports Medicine (ACSM)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 30 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults aged 18 to 40 * Both genders * BMI ≥ 30 kg/m\^2 and \< 40 kg/m\^2 * Signed informed consent form Exclusion Criteria: * Participants who smoke * Personal and family history of vascular disease or deep vein thrombosis * Clinical diagnosis of hypothyroidism * Clinical diagnosis of type 1 diabetes mellitus * Clinical diagnosis of type 2 diabetes mellitus * Clinical diagnosis of grade 3 obesity * Clinical diagnosis of hypertension * Clinical diagnosis of acute myocardial infarction or angina pectoris * Use of nitrates and calcium channel blockers within 4 days prior to the start of the study * Use of anticoagulants * Use of beta-blockers or hypoglycemic agents within 7 days prior to the intervention * Pregnant women * Breastfeeding women * Men consuming more than 40 g of alcohol per day or women consuming more than 20 g per day * Postural and biomechanical disorders (knee, foot, and spine)

Locations (1)

Centro Universitario de Tlajomulco

Tlajomulco de Zúñiga, Jalisco, Mexico

Outcomes

Primary Outcomes

Muscle strength

Muscle strength (kg): Change from baseline to 8 weeks of intervention. Muscle strength will be assessed using dynamometry