Medical students frequently experience high levels of stress, anxiety, and depression due to intense academic pressures. While spending time outdoors in nature is a proven way to reduce these negative feelings, students rarely have the time to do so. This study aims to find out if using a 360-degree Virtual Reality (VR) headset to experience immersive nature environments can provide similar relaxing benefits. The main question this study attempts to answer is whether the type of nature environment matters: Does watching a familiar, local Malaysian nature scene reduce stress more or less effectively than watching a novel, overseas nature scene? The researchers hypothesize that a brief, 15-minute exposure to either 360-degree VR nature environment will successfully reduce short-term feelings of stress, anxiety, and depression. Furthermore, they hypothesize that there will be a measurable difference in the psychological benefits between the local and overseas environments, driven by either the comfort of familiarity (local) or the distraction of escapism (overseas).
Background and Rationale: Accessible, non-pharmacological interventions are increasingly necessary to support the mental wellness of university cohorts facing high academic strain. While the restorative effects of natural environments on human psychology are well-documented, physical access to such spaces is often limited in urban academic settings. 360-degree Virtual Reality (VR) offers a highly immersive, scalable alternative. By simulating spatial presence, VR can trigger physiological and psychological relaxation responses similar to actual nature exposure. However, a gap remains in the literature regarding the semantic content of the VR exposure. Specifically, it is unclear whether the therapeutic efficacy of VR nature exposure is heavily influenced by environmental familiarity (which may foster psychological safety and place attachment) versus environmental novelty (which may promote greater cognitive distraction and escapism). Study Design and Randomization: This protocol utilizes a randomized, parallel-group behavioral trial design. To ensure group equivalence and minimize gender as a potential confounding variable in psychological stress reporting, a custom-developed Python script will be utilized to execute stratified randomization. This algorithm ensures a strict 1:1 allocation ratio into either the active local environment arm or the active overseas environment arm, while maintaining a perfectly balanced male-to-female ratio within each experimental group. Intervention Delivery and Statistical Plan: Participants undergo a structured behavioral intervention consisting of immersive 360-degree VR video viewing via a head-mounted display. The protocol requires two identical exposure sessions, separated by a strict two-week interval to evaluate repeated-dose efficacy and short-term trajectory. All self-reported psychological and well-being metrics are collected at baseline, immediately post-initial exposure, and immediately post-secondary exposure. Data will be evaluated utilizing a repeated-measures analysis of variance (ANOVA). This statistical approach is specifically chosen to assess two primary effects: the main effect of time (evaluating the overall impact of the VR intervention across all participants throughout the two-week study period) and the interaction effect of time and group (determining if there is a statistically significant divergence in the trajectory of symptom reduction between the local and overseas experimental arms).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Enrollment
82
Participants undergo a 15-minute viewing of a 360-degree local environment video via a VR headset. This session is repeated once, exactly two weeks after the initial session.
Participants undergo a 15-minute viewing of a 360-degree overseas environment video via a VR headset. This session is repeated once, exactly two weeks after the initial session.
Psychiatry Department, Hospital Canselor Tuanku Muhriz UKM
Cheras, Selangor, Malaysia
Change in Depression, Anxiety, and Stress Severity (DASS-21)
Evaluated using the Depression, Anxiety and Stress Scale-21 Items (DASS-21). This 21-item self-report questionnaire measures the core symptoms of depression, anxiety, and stress across three 7-item subscales. Items are rated on a 4-point Likert scale. Raw subscale scores are summed and multiplied by two to calculate final subscale scores. Higher scores indicate a greater severity of negative emotional symptoms.
Time frame: Baseline (T0 - immediately before the first 15-minute intervention), Day 0 (T1 - immediately after the first intervention), and Week 2 (T2 - immediately after the second intervention).
Change in Subjective Psychological Well-Being (WHO-5)
Evaluated using the WHO-5 Well-Being Index. This 5-item self-report questionnaire measures subjective psychological well-being. Items are rated on a 6-point scale from 0 ("At no time") to 5 ("All of the time"). The raw score (ranging from 0 to 25) is multiplied by 4 to convert it to a percentage scale from 0 to 100. Higher scores reflect better subjective well-being.
Time frame: Baseline (T0 - immediately before the first 15-minute intervention), Day 0 (T1 - immediately after the first intervention), and Week 2 (T2 - immediately after the second intervention).
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.