Effect of Different Concentrations of Sevoflurane for Anesthesia Induction in Pediatric Ophthalmic Surgery

Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong80 enrolled

Overview

This randomized controlled trial aims to compare the effectiveness and safety of 6% versus 8% sevoflurane inhalation induction in pediatric patients undergoing minor ophthalmic surgery. The primary outcome is emergence agitation assessed using the Pediatric Anesthesia Emergence Delirium (PAED) scale. Secondary outcomes include hemodynamic parameters, induction time, recovery time, and adverse events.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Chalazion

Interventions

SevofluraneDRUG

Sevoflurane inhalation anesthesia was used for induction and maintenance of general anesthesia in pediatric patients undergoing minor ophthalmic surgery.

Eligibility

Sex: ALLMin age: 1 YearMax age: 6 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Children aged 1 to 6 years (12-72 months) * Scheduled to undergo minor ophthalmic surgery (e.g., chalazion excision) under general anesthesia * American Society of Anesthesiologists (ASA) physical status I * Assessed as suitable for inhalation anesthesia by anesthesiologists * Written informed consent obtained from parents or legal guardians Exclusion Criteria: * ASA physical status II or higher * Known hepatic or renal dysfunction * Congenital heart disease * History of malignant hyperthermia * Known allergy to sevoflurane * History of asthma or severe respiratory disease * Upper respiratory tract infection within the past 4 weeks * Anticipated difficult airway * Refusal of participation by parents or legal guardians

Outcomes

Primary Outcomes

PAED score

Measured using the Pediatric Anesthesia Emergence Delirium (PAED) scale. The PAED scale ranges from 0 to 20, with higher scores indicating more severe emergence delirium (worse outcome).

Time frame: Within 30 minutes after recovery

Secondary Outcomes

Induction time

Time from face mask placement to loss of eyelash reflex, measured in seconds.

Time frame: Immediately after anesthesia induction

Recovery time

Time from discontinuation of sevoflurane to full recovery of consciousness, measured in minutes.

Time frame: Immediately after anesthesia discontinuation

Minimum alveolar concentration (MAC)

Minimum alveolar concentration (MAC) values recorded during anesthesia maintenance.

Time frame: Perioperatively

Respiratory depression

Incidence of respiratory depression recorded during the perioperative period.

Time frame: Perioperatively

Hypoxia

Incidence of hypoxia recorded during the perioperative period.

Time frame: Perioperatively

Cough

Incidence of cough recorded during the perioperative period.

Time frame: Perioperatively

Nausea and vomiting

Incidence of nausea and vomiting recorded during the postoperative recovery period.

Time frame: Immediately after anesthesia until discharge

Effect of Different Concentrations of Sevoflurane for Anesthesia Induction in Pediatric Ophthalmic Surgery

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts