This study aims to learn why atrial fibrillation (AF), a type of irregular heartbeat, happens more often and is harder to treat in people with hypertrophic cardiomyopathy (HCM). HCM is an inherited condition where the heart muscle is thicker than usual. Researchers will study electrical signals from the heart and advanced heart imaging. By doing this, they hope to better understand how AF behaves in people with HCM and why treatments may not work as well for them. The information from this study may help improve future treatments for people who have both HCM and AF.
Study Type
OBSERVATIONAL
Enrollment
40
Guy's and St Thomas' NHS Foundation Trust
London, United Kingdom
RECRUITINGChanges in bipolar voltage, conduction velocity, refractory periods and conduction divergence of the atria in patients with HCM and AF compared to patients with AF and structurally normal hearts
Time frame: At the time of the clinical ablation procedure
Correlatation between the bipolar voltage in the atria with directly measured left atrial pressure, extent of late gadolinium enhancement and ventricular extracellular volume .
Time frame: At the time of clinical ablation procedure
Reduction in AF inducibility in silico models following simulated ablation
Time frame: Based on measurements taken during the clinical ablation procedure
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