Association of TLR7 Gene rs3853839 Polymorphism With Disease Severity in Alopecia Areata: A Case-Control Study

Benha University120 enrolled

Overview

Alopecia areata is an autoimmune, non-scarring hair loss disorder characterized by variable clinical severity. Toll-like receptor 7 (TLR7) plays a key role in innate immune activation and autoimmune responses. The rs3853839 polymorphism of the TLR7 gene has been implicated in immune-mediated diseases. This study aims to evaluate the association between TLR7 rs3853839 polymorphism and susceptibility to alopecia areata, and to assess its correlation with disease severity measured by the Severity of Alopecia Tool (SALT) score. \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

Study Type

OBSERVATIONAL

Enrollment

120

Conditions

Alopecia Areata TLRs

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria (Cases): * Clinical diagnosis of alopecia areata * Age ≥ 18 years * Both genders * Provision of written informed consent Inclusion Criteria (Controls): * Apparently healthy individuals * No personal or family history of autoimmune disease * Age- and sex-matched to patient group * Provision of written informed consent Exclusion Criteria: * Presence of other autoimmune or inflammatory disorders * Current systemic immunosuppressive therapy * Pregnancy or lactation * Refusal to participate Exclusion Criteria: \-

Locations (1)

Outcomes

Primary Outcomes

Genotype and Allele Frequency Distribution of TLR7 rs3853839

Comparison of genotype and allele frequencies of TLR7 rs3853839 polymorphism between alopecia areata patients and healthy controls.

Time frame: Baseline

Secondary Outcomes

Association Between TLR7 rs3853839 Polymorphism and Disease Severity

Evaluation of the correlation between TLR7 rs3853839 genotypes and Severity of Alopecia Tool (SALT) score among alopecia areata patients.

Time frame: Baseline