This prospective observational cohort study aims to evaluate the association between menstrual phase (determined by postoperative serum progesterone levels), intraoperative anesthetic consumption, and the incidence and severity of postoperative nausea and vomiting (PONV) in female patients undergoing cholecystectomy. Intraoperative anesthetic requirements will be recorded, and postoperative nausea and vomiting will be assessed using standardized scoring systems.
Hormonal fluctuations during the menstrual cycle may influence anesthetic requirements and susceptibility to postoperative nausea and vomiting (PONV). However, the relationship between menstrual phase and intraoperative anesthetic consumption remains unclear. This prospective observational cohort study will include female patients undergoing elective cholecystectomy under general anesthesia. No intervention will be applied beyond standard clinical practice. Intraoperative anesthetic drug consumption will be recorded quantitatively. Postoperative nausea and vomiting will be evaluated during the early postoperative period using validated assessment tools.
Study Type
OBSERVATIONAL
Enrollment
120
Intraoperative Anesthetic Agent Consumption
Total amount of anesthetic agents administered during surgery, recorded quantitatively (e.g., mg of intravenous agents and/or minimum alveolar concentration-hours of volatile anesthetics).
Time frame: From induction of anesthesia to the end of surgery
Perioperative Hemodynamic Changes
Changes in mean arterial pressure recorded intraoperatively at predefined time intervals.
Time frame: From induction of anesthesia until the end of surgery
Postoperative Vomiting
Incidence of vomiting episodes recorded during the postoperative period.
Time frame: Within 24 hours after surgery
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