The goal of this clinical trial is to explore the effect of a low-carbohydrate diet and a balanced diet. The main questions it aims to answer are: * Does a 4-week diet intervention improve anthropometric and cardiovascular parameters? * What diet is more effective in promoting weight loss and improving cardiovascular parameters? Researchers will compare a low-carbohydrate diet and a balanced diet with control group. Participants will: * Take the intervention diet or control diet for 4 weeks * will submit food records three times a week * Visit the study location 2 times for check up and test
In this study, will some questions be recorded in the questioner about sociodemographics and lifestyle habits, and body weight and height will be measured. After that, a 1-tablespoon (5 mL) fasting blood sample be collected 2 times during the study.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
135
Comparison of the difference in the composition diet
Faculty of medicine Universitas Trisakti
Jakarta, DKI Jakarta, Indonesia
Faculty of medicine Universitas Trisakti
Jakarta, DKI Jakarta, Indonesia
Triisakti University
Jakarta, DKI Jakarta, Indonesia
Change from baseline in Body Mass Index (BMI) after 4 weeks
Body mass index (BMI) will be calculated as weight in kilograms divided by the square of height in meters (kg/m²). Body weight will be measured using a Seca 876 scale (Hamburg, Germany) with an accuracy of 0.1 kg, and height will be measured using a Seca 213 stadiometer (Hamburg, Germany) with an accuracy of 0.1 cm. Measurements will be performed at baseline and at the end of the intervention.
Time frame: baseline and 4 weeks
Change from baseline in the mean seated through cuff Systolic pressure at 4 weeks
Systolic blood pressure will be measured in mmHg using an automated upper-arm blood pressure monitor (Omron HEM7120). Measurements will be taken in the seated position after a resting period and recorded at baseline \& week 4.weeks
Time frame: Baseline and 4 weeks
Change from baseline in the mean seated Diastolic pressure at 4 weeks
Diastolic blood pressure will be measured in mmHg using an automated upper-arm blood pressure monitor (Omron HEM7120). Measurements will be taken in the seated position after a resting period and recorded at baseline and week 4. weeks
Time frame: Baseline & 4 weeks
Change from baseline in Serum Apolipoprotein B (ApoB) concentration at 4 weeks
Venous blood samples will be collected from participants after an overnight fast using serum separator tubes. Serum apolipoprotein B (ApoB) concentration will be measured using an automated immunoturbidimetric assay (Tina-quant® Apolipoprotein B ver.2, Roche Diagnostics, Mannheim, Germany) on a cobas® analyzer. Results will be reported in mg/dL, and measurements will be performed at baseline and week 4.
Time frame: Baseline and week 4.
Change from baseline in serum High-Sensitivity C-Reactive Protein (hsCRP) concentration at 4 weeks
Venous blood samples will be collected from participants after an overnight fast using serum separator tubes. High-sensitivity C-reactive protein (hsCRP) concentration will be measured using a particle-enhanced immunoturbidimetric assay (Cardiac CRP High Sensitive, Roche Diagnostics, Mannheim, Germany) on a cobas® analyzer. Results will be reported in mg/L, and measurements will be performed at baseline and week 4.
Time frame: Baseline and 4 weeks
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