This study is designed to evaluate the efficacy and safety of Hydrolyzed Keratin Peptide Powder in promoting hair health in adult with mild to moderate hair damage, compared to a placebo control.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
120
Each subject takes two capsules per day for 24 weeks. Each capsule contains DAP-HAI-403 250mg.
Each subject takes two capsules per day for 24 weeks.
Global Medical Research Center Co., Ltd.
Seoul, South Korea
The change of hair elasticity
Elasticity is measured using a Universal Testing Machine (UTM) at a stretching rate of 2 cm/min, and the mean tensile resistance prior to breakage was recorded. A higher score indicates a better outcome.
Time frame: Change of the week 24 from baseline
The change of hair luster
Hair luster is evaluated using visual grading (5-point scale), glossymeter (mean value ), and scanning electron microscopy (SEM、 12-point scale ). Both visual grading and glossymeter indicate better outcomes with higher scores. For SEM, lower scores indicate better outcomes.
Time frame: Change of the week 24 from baseline
The change of Self-evaluated satisfaction
Participants assessed their satisfaction of overall changes from baseline across 7 questions, rating perceived satisfaction on a 10-point scale (1 = not at all, 10 = very much).
Time frame: Change of the week 24 from baseline
The change of Hair diameter
Hair diameter is evaluated by phototrichogram device (Folliscope 5.0) at 50× magnification. A higher score indicates a better outcome.
Time frame: Change of the week 24 from baseline
The change of Hair density
Hair density is measured using Folliscope 5.0 at 14× magnification. A higher score indicates a better outcome.
Time frame: Change of the week 24 from baseline
The change of Hair root volume
Hair root volume was quantified using I Max-plus image analysis software by measuring the angle (°) between the parting's origin and its highest lateral points-smaller angles after treatment indicated improved root lift and volume.
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Time frame: Change of the week 24 from baseline
The change of Scalp moisture
Scalp moisture is measured using the DermaLab Hydration Pin Probe. A higher score indicates a better outcome.
Time frame: Change of the week 24 from baseline
The change of Scalp TEWL
Scalp TEWL is assessed using a Tewameter TM Nano. A lower score indicates better outcomes.
Time frame: Change of the week 24 from baseline
The change of Self-improvement evaluation
Participants were asked to complete a self-evaluation questionnaire regarding their overall improvement in the study across 5 questions, rating perceived improvement on a 10-point scale (1 = no improvement, 10 = marked improvement).
Time frame: Week 24