The purpose of this research is to evaluate the performance \[sensitivity, specificity, accuracy\] of FET PET/CT imaging to detect ACTH-secreting pituitary adenoma, using operative findings and histopathology as truth standard.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
50
Patients will receive intravenous administration of radiolabeled FET (5mCi ±10%) administered 20 minutes (±10minutes) prior to the initiation of the attenuation correction CT followed by the PET acquisition encompassing the participant's head/neck, centered on the pituitary gland.
Mayo Clinic in Rochester
Rochester, Minnesota, United States
RECRUITINGSensitivity of FET PET results in comparison to histopathology
Percentage of cases where surgical findings and pathology are in agreement with \[18F\]FET-PET/MRI imaging
Time frame: Baseline
Specificity of FET PET results in comparison to histopathology
Time frame: Baseline
Accuracy of FET PET results in comparison to histopathology
Time frame: Baseline
Agreement of FET detection of ACTH-secreting pituitary with pituitary protocol MR
Percentage of cases where pituitary protocol MR results are in agreement with FET-PET imaging
Time frame: Baseline
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