ProActive Athlete Heart Program: Proposal for Cardiac Risk Screening in Former High-Intensity Athletes

N/ANot Yet RecruitingNCT07460583

Baylor Research Institute100 enrolled

Overview

AI-Guided Coronary CT Angiography Screening in Former High-Intensity Athletes

A prospective, interventional, single-center study to determine the prevalence and characteristics (burden, composition, risk features) of coronary atherosclerosis in former high-intensity athletes using AI-guided software to analyze a CCTA.

Study Type

INTERVENTIONAL

Allocation

Purpose

SCREENING

Masking

NONE

Enrollment

100

Conditions

Coronary Atherosclerosis Due to Calcified Coronary Lesion

Interventions

Coronary CTADEVICE

The Coronary CTA will be performed for each participant. These images will be analyzed using AI-software to assess plaque quantification and an ischemia analysis, if necessary.

Eligibility

Sex: ALLMin age: 30 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Former professional or collegiate high-intensity athletes (e.g., NFL alumni, Division I athletes, or equivalent competitive-level participants). * Age ≥30 years Exclusion Criteria: * eGFR \<40 mL/min/1.73 m² * Known iodinated contrast allergy * Weight \>450 lbs. (scanner table limit) * Inability to hold breath \>10 seconds * Uncontrolled arrhythmia * Contraindication to beta-blocker, Calcium Channel Blockers and nitroglycerin * Taking part in another research study that has not given their permission to participate in this one * Pregnancy

Locations (1)

Baylor Scott & White The Heart Hospital- Plano

Plano, Texas, United States

Outcomes

Primary Outcomes

Prevalence of Coronary Atherosclerosis

The primary outcome is to determine the prevalence of coronary atherosclerosis in former high-intensity athletes using AI-guided software to analyze a CCTA.

Time frame: At CCTA assessment

Coronary Atherosclerosis Characteristics

Determine the characteristics (burden, composition, risk features) of coronary atherosclerosis in former high-intensity athletes using AI-guided software to analyze a CCTA.

Time frame: At CCTA Assessment

Secondary Outcomes

Plaque Burden

The secondary outcome is to correlate plaque burden with biomarkers (Lipid panel, HbA1c).

Time frame: Day of CCTA and biomarker collection

Central Contacts

Bonnie Ostergren

CONTACT

469-814-4181 bonnie.ostergren@bswhealth.org

Data from ClinicalTrials.gov

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