This study investigates the efficacy of topical insulin in promoting healing of pemphigus vulgaris erosions. Twenty patients with pemphigus vulgaris were enrolled, each contributing three comparable lesions randomly allocated to receive long-acting insulin (insulin glargine), short-acting insulin (regular insulin), or normal saline control. Treatments were applied topically twice daily for 14 days or until complete healing.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
20
Topical application of insulin glargine (100 IU/mL) at dose of 0.1 mL per 10 cm² lesion area, applied twice daily using insulin syringe spray technique for 14 days or until complete healing
topical application of regular insulin (100 IU/mL) at dose of 0.1 mL per 10 cm² lesion area, applied twice daily using insulin syringe spray technique for 14 days or until complete healing
Topical application of 0.9% normal saline at dose of 0.1 mL per 10 cm² lesion area, applied twice daily using insulin syringe spray technique for 14 days or until complete healing
Alexandria main university hospital, Department of Dermatology and Venereology
Alexandria, Egypt
Time to Complete Healing
Number of days required for complete epithelialization of the lesion
Time frame: Up to 14 days
Lesion Surface Area Reduction
Percentage reduction in lesion surface area from baseline,Measured using ImageJ software from standardized photographs
Time frame: Baseline, Day 7, Day 14
Daily Healing Rate
Percentage of healing per day,Calculated as percentage of surface area reduction per day
Time frame: 14 days
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