This study aims to evaluate whether fire-needle combined with regular acupuncture improves pregnancy outcomes in patients with recurrent implantation failure (RIF), compared to no or regular acupuncture. A retrospective cohort study was conducted at a university-affiliated hospital. One hundred RIF patients undergoing embryo transfer between July 2024 and June 2025 were assigned to three groups: a non-acupuncture group, a regular acupuncture group, and a fire needle combination group (receiving both fire needle and regular acupuncture). Key outcome measures, including the β-hCG positive rate, clinical pregnancy rate (CPR), and miscarriage rate (MR), were compared among the three groups.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
100
no acupuncture
Regular acupuncture
fire needle combination group (receiving both fire needle and regular acupuncture)
Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China
β-hCG-positive pregnancy
Test for hCG in the blood day 14 post-transfer
Time frame: 1 year
Clinical pregnancy
ultrasonographic detection of an intrauterine gestational sac following embryo transfer
Time frame: 1 year
Miscarriage
defined as spontaneous pregnancy loss occurring after ultrasound-confirmed clinical pregnancy
Time frame: 1 year
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