Evaluation of the Impact of Interventional Treatments for Symptomatic, Severe Tricuspid Valve Insufficiency on Renal Integrity and Function, as Well as on Physical Function and Activity in Older Adults.

Change in kidney venous stasis index (KVSI)

Change in kidney venous stasis index (KVSI) measured by duplex ultrasound

Time frame: Baseline, 6 months, 12 months, and 24 months

Change in body mass index (BMI)

Change in body mass index calculated as body weight in kilograms divided by height in meters squared (kg/m²).

Time frame: Baseline, 6 months, 12 months, and 24 months

Hospitalizations due to heart failure

Number of hospitalizations due to worsening heart failure during the study period.

Time frame: Baseline, 6 months, 12 months, and 24 months

Change in disease-specific quality of life assessed with the Kansas City Cardiomyopathy Questionnaire (KCCQ-12)

Change in disease-specific quality of life measured using the Kansas City Cardiomyopathy Questionnaire short form (KCCQ-12)

Time frame: Baseline, 6 months, 12 months, and 24 months

Change in independence in activities of daily living assessed with the Katz Index

Change in independence in activities of daily living measured using the Katz Index.

Time frame: Baseline, 6 months, 12 months, and 24 months

Change in frailty assessed using the Clinical Frailty Scale (CFS)

Change in frailty status measured using the Clinical Frailty Scale (CFS)

Time frame: Baseline, 6 months, 12 months, and 24 months

Change in hand grip strength measured using a Jamar dynamometer

Change in muscle strength assessed by hand grip strength using a manual dynamometer (Jamar).

Time frame: Baseline, 6 months, 12 months, and 24 months

Change in functional mobility assessed with the Timed Up and Go Test (TUG)

Change in functional mobility measured using the Timed Up and Go Test (TUG), assessing the time required to stand up, walk three meters, turn, return, and sit down.

Time frame: Baseline, 6 months, 12 months, and 24 months

Change in urinary albumin-to-creatinine ratio (UACR)

Change in albuminuria measured as urinary albumin-to-creatinine ratio (UACR) in spot urine samples (mg/gCreatinine)

Time frame: Baseline, 6 months, 12 months, and 24 months

Prevalence of chronic kidney disease (CKD)

Presence of chronic kidney disease defined according to KDIGO criteria based on estimated glomerular filtration rate (eGFR) and markers of kidney damage.

Time frame: Baseline, 6 months, 12 months, and 24 months

Incidence of dialysis initiation

Initiation of chronic renal replacement therapy (hemodialysis or peritoneal dialysis)

Time frame: Baseline, 6 months, 12 months, and 24 months

All-cause mortality

Death from any cause during the study period

Time frame: Baseline, 6 months, 12 months, and 24 months

Change in cognitive function assessed with the Blessed Orientation-Memory-Concentration Test (BOMCT)

Change in cognitive function measured using the Blessed Orientation-Memory-Concentration Test (BOMCT)

Time frame: Baseline, 6 months, 12 months, and 24 months

Change in emotional well-being assessed with the "Allgemeine Depressionsskala" short form (ADS-K)

Change in depressive symptoms assessed using the short version of the general depression scale (ADS-K)

Time frame: Baseline, 6 months, 12 months, and 24 months

Change in body composition measured by bioelectrical impedance analysis (BIA)

Change in body composition assessed by bioelectrical impedance analysis using the AKERN BIA 101 device.

Time frame: Baseline, 6 months, 12 months, and 24 months

Change in Venous Excess Ultrasound (VExUS) Score

Change in VExUS Score (bedside ultrasound-based approach with a more comprehensive assessment of venous congestion) measured by duplex ultrasound

Time frame: Baseline, 6 months, 12 months, and 24 months