The goal of this clinical trial is to compare the induction-to-abortion time interval between women receiving Laminaria tent followed by misoprostol and those receiving misoprostol alone for mid-trimester abortion induction in women with a scarred uterus. The main question it aims to answer is: • Is the usage of laminaria japonicum as a mechanical dilator for the cervix followed by Prostaglandin E1 more effective and time saving than using prostaglandin E1 alone in induction of mid-trimester abortion in a previously scarred uterus? Researchers will compare induction-to-abortion time interval between women receiving Laminaria tent followed by misoprostol and those receiving misoprostol alone for mid-trimester abortion induction in women with a scarred uterus. Participants in Group A: induction of abortion will be started with insertion of Laminaria japonicum for 12 hours to be followed by prostaglandin E1 methyl analogue, Misoprostol according to the FIGO 2017 recommendation. Participants in Group B: induction of abortion will be carried out by prostaglandin E1 methyl analogue, Misoprostol according to the FIGO 2017 recommendation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
60
30 women will have induction of abortion by prostaglandin E1 methyl analogue, Misoprostol according to the FIGO 2017 recommendation.
Laminaria Tent will be used for induction of abortion
Ain Shams Maternity Hospital
Cairo, Egypt
Induction-to-abortion interval time.
Time taken from the start of induction of abortion till occurrence of abortion
Time frame: From enrollment to the end of abortion, an average of one week
Rate of Operative intervention
Operative intervention needed as suction \& evacuation or the need for hystrotomy
Time frame: From enrollment to the end of abortion, an average of one week
Amount of vaginal bleeding
The amount of vaginal bleeding with be assessed visually and categorized into mild, moderate \& severe.
Time frame: From enrollment to the end of abortion, an average of one week
Rate of occurrence of uterine rupture followed by hysterectomy
As a complication of the usage of Misoprostol in previous scarred uterus is uterine rupture
Time frame: From enrollment to the end of abortion, an average of one week
The amount of Misoprostol doses needed (microgram)
The doses of Misoprostol needed till expulsion of the fetus in each arm will be compared
Time frame: Group A: after removal of Laminaria till expulsion of the fetus, an average of one week while for Group B: From enrollment to the end of abortion, an average of one week
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.