Operating Room Extubation and Postoperative Outcomes in Neonates With Meningomyelocele

N/AActive Not RecruitingNCT07465055

Gaziantep City Hospital60 enrolled

Overview

Meningomyelocele is one of the most common neural tube defects requiring surgical repair in the neonatal period. Postoperative respiratory complications and the need for prolonged mechanical ventilation are important causes of morbidity in these patients. The timing of extubation may influence postoperative respiratory outcomes and the duration of neonatal intensive care unit (NICU) stay. This retrospective cohort study aims to evaluate the impact of operating room extubation on postoperative outcomes in neonates undergoing meningomyelocele repair at Gaziantep City Hospital. Clinical, laboratory, and perioperative data will be obtained from hospital records. Postoperative mechanical ventilation requirement, duration of ventilation, NICU length of stay, and perioperative laboratory changes will be compared between neonates extubated in the operating room and those extubated in the intensive care unit.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Myelomeningocele Extubation Time Neonatal

Eligibility

Sex: ALLMin age: 0 DaysMax age: 28 Days

Medical Language ↔ Plain English

Inclusion Criteria: * Neonates undergoing surgical repair of meningomyelocele * Surgery performed under general anesthesia * Age ≤ 28 days at the time of surgery * Postoperative follow-up in the neonatal intensive care unit (NICU) * Availability of complete perioperative clinical and laboratory data Exclusion Criteria: * Preoperative respiratory distress requiring invasive or non-invasive ventilatory support * Major congenital anomalies or severe comorbidities (e.g., complex congenital heart disease, severe pulmonary disease, chromosomal abnormalities) * Neonates with poor postnatal adaptation (5-minute Apgar score \< 7) * Preoperative hemodynamic instability * Severe prematurity-related respiratory morbidity * Prolonged mechanical ventilation due to causes unrelated to meningomyelocele surgery * Incomplete or missing perioperative medical records

Outcomes

Primary Outcomes

Postoperative Mechanical Ventilation Requirement

Requirement for invasive mechanical ventilation after meningomyelocele repair in neonates.

Time frame: Within the first 48 hours after surgery

Secondary Outcomes

Length of NICU Stay

Duration of stay in the neonatal intensive care unit following meningomyelocele repair.

Time frame: From surgery until discharge from the neonatal intensive care unit, up to 30 days

Change in Blood pH

Difference between preoperative and postoperative blood pH values.

Time frame: Preoperative vs postoperative 24 hours

Change in Lactate Level

Difference between preoperative and postoperative blood lactate levels.

Time frame: Baseline (preoperative) and 24 hours after surgery