A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase Ⅱ Clinical Study to Evaluate the Efficacy and Safety of CMS-D001 in Adult Patients With Moderate to Severe Atopic Dermatitis

Inclusion Criteria: * Aged 18-75 years, willing to sign the ICF * Clinical diagnosis of AD (Hanifin \& Rajka criteria) for ≥1 year * At screening and baseline, EASI score ≥ 16 points, IGA ≥ 3, BSA ≥ 10%, Itch NRS ≥ 4 * Documented history of inadequate response to topical corticosteroids (TCS) or -topical calcineurin inhibitors (TCI). * Subject has applied a topical emollient (moisturizer) daily for at least 7 days prior to the Baseline Visit. Exclusion Criteria: * Other active skin conditions that may interfere with AD assessment. * History of a serious bacterial, fungal, or viral infection requiring hospitalization or intravenous antimicrobial therapy within 3 months prior to the first dose. * History of a bacterial, fungal, or viral infection requiring oral antimicrobial therapy within 4 weeks prior to the first dose. * Active infection or acute illness within 7 days prior to the first dose. * Chronic or recurrent infectious diseases at screening or baseline that may increase safety risks. * Evidence of active TB. Patients with evidence of latent tuberculosis may enter the trial after sufficient treatment had initiated and maintained according to protocol. * History of a major or unstable clinical condition within 6 months prior to the first dose, which would compromise participation. * History of malignant tumour within 5 years before screening. * Previous or current autoimmune diseases. * Positive results of confirmatory test for hepatitis B, hepatitis C, human * immunodeficiency virus (HIV) or syphilis. * Allergic to any component of the investigational drug.