Acute Ischemic Stroke Involves Significant Inflammatory Response. This Prospective Cohort Study Evaluates the Predictive Value of Monocyte-, Neutrophil-, and Leukocyte-to-albumin Ratios for Stroke Severity and Functional Outcome Using NIHSS at Admission and Modified Rankin Scale During Follow-up.

Inclusion Criteria: * Adult patients (≥ 18 years old) admitted with a diagnosis of acute ischemic stroke confirmed by brain imaging (CT or MRI). * Admission within a defined time window from stroke onset (e.g., within 48 hours) to capture acute inflammatory response. * Availability of complete blood count (CBC) with differential and serum -albumin levels at admission. * Informed consent obtained from the patient or their legal representative. Exclusion Criteria: * Patients with hemorrhagic stroke or transient ischemic attack (TIA). * Patients with previous history of ischemic stroke. * Patients who accepted intravenous thrombolysis (IV tPA) and or mechanical thrombectomy. * Pre-existing inflammatory or autoimmune diseases (e.g., rheumatoid arthritis, lupus, inflammatory bowel disease) that could influence monocyte count or albumin levels. * Active infections (bacterial, viral, fungal) at admission. * Severe liver or kidney disease affecting albumin synthesis or catabolism. * Hematological disorders affecting white blood cell counts. ⚫ Patients on immunosuppressive therapy or corticosteroids. * Patients with known malignancy * Lack of complete blood count (CBC) with differential and serum albumin levels at admission. * Patients who received blood transfusions before blood sampling. * Patients with other acute severe medical conditions that significantly impact inflammatory markers (e.g., sepsis, major trauma).