Indicators Affecting PVT Recanalization

Shanghai Zhongshan Hospital1,500 enrolled

Overview

This is a retrospective-prospective study conducted at Zhongshan Hospital, Fudan University, to explore portal vein thrombosis (PVT) in patients with cirrhosis and gastroesophageal varices (GEV). It aimed to provide insights into the diagnosis, follow-up, and factors influencing PVT recanalization, to help patients, families, and healthcare providers understand the disease and related clinical management.

Study Type

OBSERVATIONAL

Enrollment

1,500

Conditions

Portal Vein Thrombosis Cirrhosis Portal Hypertension Related to Cirrhosis Portal Hypertension, Noncirrhotic

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * diagnosed as cirrhosis and confirmed gastroesophageal varices by endoscopy; * all patients were diagnosed as PVT by CTA at admission. Exclusion Criteria: * patients with hepatocellular carcinoma; * patients with extrahepatic malignancies; * history of liver transplantation or TIPS; * lack of information regarding anticoagulation therapy； * those with cavernous transformation of the portal vein(CTPV) .

Outcomes

Primary Outcomes

PVT recanalization at 1 year

Time frame: From the first abdominal imaging assessment after admission, until the occurrence of PVT recanalization at 1 year, death, or the last follow-up, whichever came first

Secondary Outcomes

Occurrence of all-cause death (competing event)

Time frame: From the date of admission confirmation of PVT to the occurrence of death, or the last follow-up, whichever came first

PVT recanalization at 5 years

Time frame: From the first abdominal imaging assessment after admission, until the occurrence of PVT recanalization at 5 year, death, or the last follow-up, whichever came first

Occurrence of non-improved PVT

defined as unchanged thrombus size, \<50% thrombus reduction, or thrombus extension to new venous segments

Time frame: From the date of admission confirmation of PVT to the last radiological follow-up at 1 year, or death, whichever came first