The aim of the present study is to gain more information about retinal functional parameters in myopic children in Europe. For this purpose, a prospective case-control study in children aged between 8 and 13 years, as this is the usual age of myopia onset, will be conducted. Forty myopic children will be age- and sex-matched to non-myopic controls. Retinal oxygen extraction will be used as the main outcome parameter, as data from animal and human studies point towards an involvement of hypoxia in the disease process. In addition, other parameters probably linked to myopia will be investigated, such as retinal and choroidal blood flow as well as choroidal and retinal vessel density and anatomical structures such as choroidal and central retinal thickness. Also, questionnaires about lifestyle factors will be completed.
Study Type
OBSERVATIONAL
Enrollment
80
Department of Clinical Pharmacology, Medical University of Vienna, Austria
Vienna, Austria
Retinal oxygen extraction
Retinal oxygen extraction measured with LSFG and RVA
Time frame: Study Day 1
Choroidal and retinal blood flow
Choroidal and retinal blood flow measured with LSFG
Time frame: Study Day 1
Choroidal and central retinal thickness
Choroidal and central retinal thickness measured with OCT
Time frame: Study Day 1
Retinal and choroidal vessel density
Retinal and choroidal vessel density measured with OCT-A
Time frame: Study Day 1
Lifestyle factors
Lifestyle factors with questionnaires
Time frame: Study Day 1
Axial eye length
Axial eye length measured with IOL-Master
Time frame: Study Day 1
Intraocular pressure
Intraocular pressure measured with rebound tonometer
Time frame: Study Day 1
Refraction in cycloplegia
Refraction in cycloplegia measured with Autorefractometer
Time frame: Study Day 1
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