Human Repeat Insult Patch Test to Evaluate Skin Irritation and Sensitization in Healthy Volunteers

Inclusion Criteria: * Adults aged 18 to 70 years * Male and female participants * Fitzpatrick Skin Types I and VI * Participants of any race * Participants of any ethnicity (Hispanic or Latino or Not Hispanic or Latino) * Generally healthy, without dermatological or systemic conditions that could interfere with study participation or evaluation of results, as determined by the investigator * Able to read and understand English and provide written informed consent * Able to comply with study procedures and complete all required visits * Willing to have test materials applied according to the study protocol * Has not participated in a similar clinical study within the previous 30 days * Agrees to avoid excessive sun exposure, sunbathing, or tanning during study participation * Female participants of childbearing potential willing to undergo pregnancy testing prior to participation * Agrees not to change current personal care products during study participation Exclusion Criteria: * Use of medications that may interfere with study results (e.g., corticosteroids, antihistamines, immunosuppressive agents, or high-dose NSAIDs) * History of acute or chronic medical conditions that could interfere with study participation or increase risk (e.g., autoimmune disease, HIV infection) * Chronic skin conditions such as atopic dermatitis or eczema * Treatment for skin cancer within the previous 12 months * Abnormal or damaged skin at test sites that could interfere with evaluation (e.g., sunburn, tattoos, scars, active dermatologic conditions) * Diabetes requiring insulin therapy * Pregnant, planning pregnancy, or breastfeeding * Known hypersensitivity to personal care products, cosmetics, fragrances, or adhesives * Known fish allergy * Any condition that, in the opinion of the investigator, may compromise participant safety or study integrity