Image Guided Genicular Nerve Radiofrequency Ablation for Chronic Knee Osteoarthritis

N/ANot Yet RecruitingNCT07475793

Aga Khan University52 enrolled

Overview

The goal of this prospective randomized control trial is to provide continued pain relief, classically long-lasting 3 to12 months, and enhanced function in patients following: both gender; male and female, age group; \>50yr, healthy volunteers along with Radiographic diagnosis of knee OA with KL grade 3 and 4 in addition of Chronic knee pain ≥ 6 months and patients with ≥50% decrease in pain strength after diagnostic genicular nerve block. The main question it aims to answer is: Is ultrasound-guided genicular nerve RFA more efficient in lowering pain intensity at six months contrasted with fluoroscopic guided method in patients with chronic knee osteoarthritis? Researchers will compare Group A (Fluoroscopic) to Group B (Ultrasound) to see comparison in efficiency of ultrasound guided against fluoroscopic guided genicular nerves block for decrease in pain intensity and functional improvement.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Chronic Knee Osteoarthritis

Interventions

Eligibility

Sex: ALLMin age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Both gender patients of age more than 50 years. * Radiographic diagnosis of knee OA with KL level 3 and 4. * Chronic knee pain for more than 6 months * Patients with more than 50% reduction in pain intensity after diagnostic genicular nerve block Exclusion Criteria: * Lack of consent * surgery of knee * Patient with BMI more than 40kg/m2 * Intra-articular steroid injection or hyaluronic acid in last 3 months * Localized infection at procedure site or knee. * Patient unable to communicate properly (Severe psychiatric illness, severe dementia and cognitive impairment). * Patients have moderate to severe low back pain (NRS ≥5)

Outcomes

Primary Outcomes

Effectiveness of Block

Block will be considered effective if decrease in pain score from baseline is \>50% at six months. And this will measure by using the 11-point Numeric Rating Scale (NRS) where 0 = no pain and 10 = worst imaginable pain.

Time frame: Post procedure 2 weeks, then follow up after 2, 4 and 6 months.

Secondary Outcomes

Functional Improvement after block

Functional improvement after genicular nerve block is describe as \> 20 % decrease in KOOS PS score from baseline at six months. Functional condition will be assessed using the Knee injury and osteoarthritis outcomes score-Physical function short form (KOOS-PS) tool. Minimum score is 0 and maximum is 20 which will then be converted into ratio from 0 to 100%, 0 means no functional impairment and 100 means maximum functional impairment.

Time frame: 6 months