Targeted temporal interference stimulation (tTIS) of the caudate nucleus can modulate the abnormal electrophysiological activity in individuals with methamphetamine use disorder (MUD), thereby improving their impaired reward-learning behaviors and reducing drug craving.
This project will recruit MUD patients. A 5-day intervention protocol of real or sham tTIS targeting the caudate nucleus will be employed. Before and after intervention, drug craving anddrug use and other questionnaire as well as stop-signal tasks, and reward-learning tasks will be used to evaluate its therapeutic efficacy on clinical craving and the underlying neural mechanisms.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
60
The stimulation duration are 30 minutes per session, administered twice daily for 5 consecutive days.
The stimulation parameters-including frequency, current intensity, and duration-are identical to those in the active group. However, the sham stimulation mode is activated on the device, resulting in no actual current being delivered during the stimulation.
Shanghai Mental Health Center
Shanghai, Shanghai, Shanghai, China, 200000, China
Change of Craving
Visual Analog Scale, range0-100 point. the higher the score, the more one wants drugs.
Time frame: baseline, 1 day after treatment, 7 day after treatment, 2 weeks after treatment, 13 weeks after treatment
Drug Use
OCDUSE scale
Time frame: baseline, 1 day after treatment, 7 day after treatment, 2 weeks after treatment, 13 weeks after treatment
impulsivity
This study employed the BIS-11 Impulsiveness Scale
Time frame: baseline, 1 day after treatment, 7 day after treatment, 2 weeks after treatment, 13 weeks after treatment
impulsivity
the Impulsive-Control Dual Systems Scale
Time frame: baseline, 1 day after treatment, 7 day after treatment, 2 weeks after treatment, 13 weeks after treatment
impulsivity
Stop Single Task
Time frame: baseline, 1 day after treatment, 7 day after treatment, 2 weeks after treatment, 13 weeks after treatment
Changes in Reward Learning
Reward LearningTask
Time frame: baseline, 1 day after treatment, 7 day after treatment, 2 weeks after treatment, 13 weeks after treatment
Decision-making Preferences and Delay of Gratification
delay discounting task
Time frame: baseline, 1 day after treatment, 7 day after treatment, 2 weeks after treatment, 13 weeks after treatment
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sensitivity to reward and punishment
the Sensitivity to Punishment and Sensitivity to Reward Questionnaire, the Cognitive Flexibility Scale, the Behavioral Inhibition/Activation System Scale
Time frame: baseline, 1 day after treatment, 7 day after treatment, 2 weeks after treatment, 13 weeks after treatment
emotional states
the BDI Depression Inventory
Time frame: baseline, 1 day after treatment, 7 day after treatment, 2 weeks after treatment, 13 weeks after treatment
emotional state
the BAI Anxiety Inventory
Time frame: baseline, 1 day after treatment, 7 day after treatment, 2 weeks after treatment, 13 weeks after treatment
sleep quality
the PSQI Sleep Quality Index
Time frame: baseline, 1 day after treatment, 7 day after treatment, 2 weeks after treatment, 13 weeks after treatment
EEG
source power of each frequency band
Time frame: baseline, 1 day after treatment, 7 day after treatment, 2 weeks after treatment
EEG
change of functional connection of brain area
Time frame: baseline, 1 day after treatment, 7 day after treatment, 2 weeks after treatment