A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

Change in WOMAC physical function score

Measured as score on a scale. Physical function score will be calculated according to the guidelines provided in the WOMAC User Guide XI. Score ranges from 0-100 and higher scores indicate worse physical function.

Time frame: From baseline (week 0) to (week 80)

Change in SF-36v2® Health Survey Acute (SF-36v2 Acute) physical functioning score

Measured as score on a scale. SF-36v2 Acute measures Health-Related Quality of Life (HRQOL). The measure consists of 36 items yielding 8 health domain scores and 2 component summary scores. SF-36v2 Acute scores are norm-based scores, that is transformed to a scale where the 2009 US general population has a mean of 50 and a standard deviation (SD) of 10. Higher scores indicate better functional health and well-being. The physical functioning ranges from 19.0 to 57.6.

Time frame: From baseline (week 0) to (week 80)

Change in body weight

Measured as kilogram (kg).

Time frame: From baseline (week 0) to (week 80)

Change in body mass index (BMI)

Measured as kilograms per meter squared (kg/m\^2).

Time frame: From baseline (week 0) to (week 80)

Change in WOMAC stiffness score

Measured as score on a scale. Stiffness score will be calculated according to the guidelines provided in the WOMAC User Guide XI. Score ranges from 0-100 and higher scores indicate worse stiffness.

Time frame: From baseline (week 0) to (week 80)

Change in WOMAC total score

Measured as score on a scale. Total score will be calculated according to the guidelines provided in the WOMAC User Guide XI. Total score ranges from 0-100 and higher scores indicate worse overall osteoarthritis- related disability.

Time frame: From baseline (week 0) to (week 80)

Change in waist circumference

Measured as centimetre (cm).

Time frame: From baseline (week 0) to (week 80)

Change in systolic blood pressure (SBP)

Measured as millimetre of mercury (mmHg).

Time frame: From baseline (week 0) to (week 80)

Change in diastolic blood pressure (DBP)

Measured as mmHg.

Time frame: From baseline (week 0) to (week 80)

Change in total cholesterol

Measured as ratio to baseline.

Time frame: From baseline (week 0) to (week 80)

Change in high-density lipoprotein (HDL) cholesterol

Measured as ratio to baseline.

Time frame: From baseline (week 0) to (week 80)

Change in low-density lipoprotein (LDL) cholesterol

Measured as ratio to baseline.

Time frame: From baseline (week 0) to (week 80)

Change in very low-density lipoprotein (VLDL) cholesterol

Measured as ratio to baseline.

Time frame: From baseline (week 0) to (week 80)

Change in non-HDL cholesterol

Measured as ratio to baseline.

Time frame: From baseline (week 0) to (week 80)

Change in triglycerides

Measured as ratio to baseline.

Time frame: From baseline (week 0) to (week 80)

Change in high-sensitivity C-reactive protein (hsCRP)

Measured as ratio to baseline.

Time frame: From baseline (week 0) to (week 80)

Change in glycated haemoglobin (HbA1c)

Measured as percentage (%) of HbA1c.

Time frame: From baseline (week 0) to (week 80)

Change in fasting plasma glucose (FPG)

Measured as millimole per liter (mmol/L).

Time frame: From baseline (week 0) to (week 80)

Number of participants allowed using rescue analgesics during washout period (Yes/no)

Measured as number of participants

Time frame: From baseline (week 0) to (week 80)

Amount of allowed rescue analgesics used during washout period

Measured as dose of analgesics.

Time frame: From baseline (week 0) to (week 80)

Use of pain medication (Yes/No)

Measured as number of participants.

Time frame: From baseline (week 0) to (week 80)

Amount of pain medication used

Measured as dose of pain medication.

Time frame: From baseline (week 0) to (week 80)

Number of participants with change in pain medication (decrease/no change/increase)

Measured as number of participants.

Time frame: From baseline (week 0) to (week 80)

Change in knee pain intensity (NRS)

Measured as score on a scale. Knee pain numerical rating scale (NRS) measures knee pain at its worst in the last 24 hours. The measure consists of 1 item. The response scale is an 11-point numeric rating scale from 0 (No knee pain) to 10 (Worst possible knee pain). Higher scores indicate worse pain.

Time frame: From baseline (week 0) to (week 80)

Number of treatment Emergent Adverse Events (TEAEs)

Measured as number of events.

Time frame: From baseline (week 0) to week 84

Number of treatment Emergent Serious Adverse Events (TESAEs)

Measured as number of events.

Time frame: From baseline (week 0) to week 84

Number of TEAEs leading to permanent treatment discontinuation

Measured as number of events.

Time frame: From baseline (week 0) to week 84