Magnetic Resonance Imaging of the Lung: Oncological Applications

Fondazione IRCCS Policlinico San Matteo di Pavia50 enrolled

Overview

Lung neoplasms are characterized by a complex interaction between tumor cells and a variety of resident and infiltrating host elements, secreted factors, and extracellular matrix proteins, collectively referred to as the microenvironment. Nowadays, in the setting of lung cancer, and in particular non-small cell lung cancer (NSCLC), the evaluation of microenvironment characteristics can only be performed by a pathologist and only on histological material. By combining different MRI parameters, it may be possible to create a specific imaging "signature" for the three different immune phenotypes and thus be able to make a distinction based on MRI examination.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Lung Cancer (NSCLC)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Primary NSCLC of the lung (TNM 8th edition T parameter ≥T1c) * Biopsy examination of the primary tumor adequate at least for PDL-1 quantification * Staging CT scan with uncertain N parameter and definite M parameter. Exclusion Criteria: * Absolute contraindications to magnetic resonance imaging or the administration of gadolinium-based contrast agents

Locations (1)

Fondazione IRCCS Policlinico San Matteo

Pavia, Italy

Magnetic Resonance Imaging of the Lung: Oncological Applications

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Central Contacts