The objective of this study is to evaluate the efficacy and safety of Small-molecular-weight deer antler collagen (NP-2007) on skin health, including skin hydration, transepidermal water loss (TEWL), elasticity, and eye wrinkles.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
84
Corederm Skin Research Center
Seoul, South Korea
Change from Baseline in Skin Hydration at 12 weeks
Measured using Corneometer® CM 825. The unit of measure is arbitrary units (AU) ranging from 0 to 120. Higher scores indicate improved skin moisture.
Time frame: Baseline, 6 weeks, 12 weeks
Change from Baseline in Transepidermal Water Loss (TEWL) at 12 Weeks
Measured using Tewameter® TM 300. The unit of measure is g/m²/h. Lower values indicate improved skin barrier function.
Time frame: Baseline, 6 weeks, 12 weeks
Change from Baseline in Skin Scaling at 12 Weeks
Evaluated using D-Squame® and image analysis. Higher values indicate more scaling (worse), lower values indicate improvement.
Time frame: Baseline, 6 weeks, 12 weeks
Change from Baseline in Skin Roughness at 12 Weeks
Measured using Visiometer® SV 700. Assesses the texture of the skin surface. Lower values indicate smoother skin.
Time frame: Baseline, 6 weeks, 12 weeks
Change from Baseline in Eye Wrinkles (Ra) at 12 Weeks
Quantitative analysis of eye wrinkles (crow's feet) using Visiometer® SV 700. Ra represents the average roughness in millimeters (mm). Lower values indicate improved wrinkle depth.
Time frame: Baseline, 6 weeks, 12 weeks
Change from Baseline in Skin Elasticity (R2) at 12 Weeks
Measured using Cutometer® MPA 580. R2 represents gross elasticity (0 to 1 scale). Higher values indicate better skin elasticity.
Time frame: Baseline, 6 weeks, 12 weeks
Investigator's Visual Assessment Grade for Eye Wrinkles
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Baseline, 6 weeks, 12 weeks Clinical grading of eye wrinkle severity by a dermatologist using a visual analog scale. The scale ranges from 0 to 9, where 0 indicates 'None' (no wrinkles) and 9 indicates 'Very Severe' wrinkles. A decrease in the score (lower values) represents a better outcome (improvement in wrinkles).
Time frame: Clinical grading of eye wrinkle severity by a dermatologist. The grade is based on a visual scale from 0 to 9 (0 = None, 9 = Very Severe). Lower grades indicate clinical improvement in wrinkle severity.
Participant Subjective Questionnaire Assessment for Skin Improvement
6 weeks, 12 weeks Participants' self-assessment of skin improvement using a 5-point Likert scale. The scale ranges from 1 to 5, where 1 indicates 'Very Dissatisfied' and 5 indicates 'Very Satisfied'. A higher score represents a better outcome (higher satisfaction and perceived efficacy).
Time frame: Participants assess skin improvement and satisfaction through a self-report questionnaire using a 5-point Likert scale (1 = Very Dissatisfied, 5 = Very Satisfied). Higher scores indicate greater satisfaction with the product's efficacy.