The purpose of this study is to demonstrate dose strength equivalence of 2 × 164.4 milligrams (mg) centanafadine (CTN) once daily (QD) extended-release (XR) capsules to a 1 × 328.8 mg centanafadine QD XR capsule in healthy adult participants.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
44
Centanafadine will be administered as an oral capsule.
ICON plc
Lenexa, Kansas, United States
Maximum Plasma Concentration (Cmax) of Centanafadine
Time frame: Up to Day 5
Area Under the Concentration-time Curve Calculated to the Last Observable Concentration at Time t (AUCt) of Centanafadine
Time frame: Up to Day 5
Area Under the Concentration-time Curve From Time Zero to Infinity (AUCinfinity) of Centanafadine
Time frame: Up to Day 5
Time to Reach Maximum Plasma Concentration (Tmax) of Centanafadine
Time frame: Up to Day 5
Percentage (%) of Extrapolated AUC of Centanafadine
Time frame: Up to Day 5
Terminal Phase Elimination Half-life (t1/2,z) of Centanafadine
Time frame: Up to Day 5
Apparent Clearance from Plasma (CL/F) After Extravascular Administration of Centanafadine
Time frame: Up to Day 5
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