Pilot Exploration of Platelet Characterization of Platelet Rich Plasma Created by Two Different Systems

Inclusion Criteria: * Kellgren-Lawrence (KL) Grade 1-3 knee osteoarthritis * Symptoms of knee osteoarthritis for at least 3 months before presentation in one knee * Will be able to attend and perform physical therapy Exclusion Criteria: * Received injection therapy for knee osteoarthritis in the past 6 months * Have severe arthritis diagnosed in ≥1 major joint by radiology criteria * History of septic arthritis * Underwent knee surgery for osteoarthritis or osteochondral defects within 1 year before randomization (e.g., autograft or allograft surgery) * Have had high tibial osteotomy, partial knee replacement, patellar resurfacing, total knee replacement, or have existing surgical hardware in the knee * Received a platelet-rich plasma injection elsewhere in the body within the past 3 months * Have a platelet disorder or bleeding disorder * Have a rheumatologic disease, autoimmune disorder, immunocompromised status, or active history of cancer * Are taking chemotherapy, require regular prednisone, or require regular anti-inflammatory use * Are pregnant, breastfeeding, or unwilling to practice birth control during the study * If both knees have osteoarthritis and the other knee has KL score equal to or greater than 2. * Have uncontrolled illness, physical disability, or other contraindication to aerobic exercise training