Effect of Nicotine Gingival Fibroblast Intoxication on the Response of Periodontal Treatment

N/AEnrolling By InvitationNCT07491627

University of Liege56 enrolled

Overview

Impact of nicotine gingival intoxication on the clinical outcomes after periodontitis non surgical treatment

In patients suffured of periodontitis, to evaluate the effect of nicotine gingival tissue intoxication and others smoking indicators on the severity of periodontitis and outcomes after nonsurgical periodontal treatment."

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Periodontitis Smoking Cessation Tobacco Dependence

Interventions

periodontal non-surgical treatmentPROCEDURE

The procedure will consist of non-surgical periodontal treatment (NSPT), consisting of the removal of supra- and subgingival plaque using ultrasonic instruments. Prior to the NSPT, all unstimulated saliva will be collected using Eppendorf. During local anesthesia for the NSPT, a gingival tissue biopsy will be performed using a 2mm wide and 4mm deep punch in the maxillary retromolar area behind the last tooth in the arch.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: patient suffured of periodontitis, smoker and non-smoker * patient suffured of periodontitis * smoker and non-smoker * presence of a minimum of 6 teeth at each arch * minimum of 6 teeth with pocket depth of 5 mm * signed informed consent Exclusion Criteria: * diabetes, * connective tissue disease * pregnancy * radiotherapy * chemotherapy * psychological disease * previous periodontal therapy * antibiotics intake

Locations (1)

Departement of periodontology, buccal surgery and implantology- Uliège, Belgium

Liège, Liege, Belgium

Outcomes

Primary Outcomes

nicotine/cotinine in gum (ng/ml)

concentration cotinine and nicotine (ng/ml)

Time frame: the day of the periodontal non surgical treatment

Secondary Outcomes

PD (mm)

periodontal pocket depth (mm) Secondary outcomes: percentage of sites with PD ≥ 6 mm, furcation involvement, mobility assessment, bleeding on probing score (BoP), plaque score (PI).

Time frame: baseline, the day of periodontal non- surgical treatment(PNST) , 3,6 and 12 months after PNSTs after

% PD ≥ 6 mm (%)

percentage of sites with PD ≥ 6 mm

Time frame: baseline, the day of periodontal non- surgical treatment(PNST) , 3,6 and 12 months after PNSTs after

FTND score ( 0 to 9)

Fagerström test for nictnie dependance ( scale from 0 to 9)

Time frame: the day of periodontal non-surgical treatment

PY (number/year)

number of packet of cigarettes smoked per year

Time frame: the day of periodontal non-surgical treatment

NCC (0 to 100)

number of cigartes consummed per day * PK: number of packet of cigarettes smoked per year * FTND: Fagerström test for nictnie dependance

Time frame: the day of periodontal non-surgical treatment

Furc (I,II or III)

furcation involvement

Time frame: baseline, the day of periodontal non- surgical treatment(PNST) , 3,6 and 12 months after PNSTs after

Data from ClinicalTrials.gov

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