Spontaneous Breathing Mode: A Risk for Hypoxemia During OLV?

N/AEnrolling By InvitationNCT07494006

Peking University People's Hospital44 enrolled

Overview

Patients undergoing thoracic surgery with one-lung ventilation (OLV) are prone to hypoxemia, which is primarily attributable to pulmonary ventilation-perfusion (V/Q) mismatch. This study will preoperatively assess the distribution of pulmonary ventilation under spontaneous breathing and intraoperatively record the lowest peripheral oxygen saturation (SpO₂) during OLV. The aim is to investigate the correlation between these two parameters. The findings are expected to facilitate the prediction of hypoxemia in thoracic surgical patients undergoing OLV.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Lung Cancer OLV Hypoxemia During Surgery

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥ 18 years * BMI \> 18.5 and \< 30 * Informed consent obtained Exclusion Criteria: * • Inability to use the EIT belt preoperatively * Failure to implement one-lung ventilation during surgery

Locations (1)

Peking University People's Hospital

Outcomes

Primary Outcomes

Lowest SpO₂ during OLV

We will record the value of the lowest peripheral oxygen saturation (SpO₂) during intraoperative one-lung ventilation.

Time frame: Perioperative

Secondary Outcomes

Postoperative functional status

After hospital discharge, The Lung Cancer Symptom Scale (LCSS) questionnaires will be administered to patients via telephone by trained follow-up personnel. LCSS typically includes items that evaluate the intensity of symptoms such as cough, dyspnea, pain, fatigue, appetite loss, and insomnia, as well as the impact of these symptoms on daily activities. Each item is rated on a numerical scale, and the total score reflects the overall symptom burden, with higher scores indicating more severe symptoms.

Time frame: Follow-up assessments with both questionnaires were conducted at 6 and 12 months postoperatively.

postoperative quality of life

After hospital discharge, The Cancer Therapy-Lung (FACT-L) questionnaire will be administered to patients via telephone by trained follow-up personnel. FACT-L is a widely used quality-of-life questionnaire that combines the general FACT-G (General) items with a lung-cancer-specific (LCS) module .Scores are calculated for each domain and a total score, with higher scores indicating better quality of life.

Time frame: Follow-up assessments with both questionnaires were conducted at 6 and 12 months postoperatively.