To evaluate the absorption, metabolism and excretion after a single intravenous bolus of \[14C\]HRS-9190 in healthy Participants
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
6
\[14C\] HRS-9190 for injection
First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital)
Jinan, Shandong, China
Total radioactive recovery rate and cumulative total radioactive recovery rate of excreta
Time frame: From 0 to 120 hours after dosing
Percentage of unchanged HRS-9190 and its metabolites in the total radioactive exposure in plasma
Time frame: From 0 to 120 hours after dosing
Percentage of unchanged HRS-9190 and its metabolites in urine and feces relative to the administered dose
Time frame: From 0 to 120 hours after dosing
List of metabolites identified in plasma, urine, and feces
Time frame: From 0 to 120 hours after dosing
Total radioactive pharmacokinetic parameter Tmax
Time frame: From 0 to 120 hours after dosing
Total radioactive pharmacokinetic parameter Cmax
Time frame: From 0 to 120 hours after dosing
Total radioactive pharmacokinetic parameter t1/2
Time frame: From 0 to 120 hours after dosing
Total radioactive pharmacokinetic parameter MRT
Time frame: From 0 to 120 hours after dosing
Total radioactive pharmacokinetic parameter AUC
Time frame: From 0 to 120 hours after dosing
The whole blood-plasma radioactive distribution ratio
Time frame: From 0 to 120 hours after dosing
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Adverse events
Time frame: up to 13 days postdose
Plasma concentration of HRS-9190 (metabolites, if necessary)
Time frame: From 0 to 120 hours after dosing