This study investigates low-load, cuff-assisted training to improve mitochondrial capacity. The intervention is carried out using automated pressure cuffs, applying an individualized pressure of 70% of the limb occlusion pressure. This approach reflects the current scientific consensus for safe and effective use in clinical populations. Within a rehabilitation setting, two training modalities are compared: intermittent strength training and alternating continuous endurance training. Muscle oxygen saturation is measured non-invasively using near-infrared spectroscopy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
51
Pre/Post comparison of mitochondrial capacity of the m. vastus lateralis muscle and muscle morphology between the groups.
Pre/Post comparison of mitochondrial capacity of the m. vastus lateralis muscle and muscle morphology between the groups
Pre/Post comparison of mitochondrial capacity of the m. vastus lateralis muscle and muscle morphology between the groups
Determination of changes in the mitochondrial capacity of skeletal muscle (of the thigh muscle, vastus lateralis; measured non-invasively)
Time frame: From enrollment to the end of treatment at 6 weeks.
Minimum and maximum oxygen saturation (SmO₂) during application of pressure cuffs (measured via NIRS)
Time frame: From enrollment to the end of treatment at 6 weeks.
Changes in total hemoglobin (tHb) as a measure of local blood volume (measured via NIRS)
Time frame: From enrollment to the end of treatment at 6 weeks.
Assessment of subjective functional mobility using the "Lower Extremity Functional Scale" (LEFS) questionnaire
Maximal Score: 80; Minimal Score: 0; Higher Score indicates better functional mobility
Time frame: From enrollment to the end of treatment at 6 weeks.
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